University of Massachusetts Medical School Faculty Publications

Title

Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer

UMMS Affiliation

Division of Genes and Development, Department of Pediatrics; Department of Biochemistry and Molecular Pharmacology; Imbalzano Lab; Nickerson Lab

Publication Date

2019-07-01

Document Type

Article

Disciplines

Amino Acids, Peptides, and Proteins | Biochemistry, Biophysics, and Structural Biology | Cancer Biology | Cell Biology | Cells | Genetic Phenomena | Genetics and Genomics | Neoplasms

Abstract

Cells establish and sustain structural and functional integrity of the genome to support cellular identity and prevent malignant transformation. In this review, we present a strategic overview of epigenetic regulatory mechanisms including histone modifications and higher order chromatin organization (HCO) that are perturbed in breast cancer onset and progression. Implications for dysfunctions that occur in hormone regulation, cell cycle control, and mitotic bookmarking in breast cancer are considered, with an emphasis on epithelial-to-mesenchymal transition and cancer stem cell activities. The architectural organization of regulatory machinery is addressed within the contexts of translating cancer-compromised genomic organization to advances in breast cancer risk assessment, diagnosis, prognosis, and identification of novel therapeutic targets with high specificity and minimal off target effects.

Keywords

RUNX, breast cancer, cancer stem cells, epithelial to mesenchymal transition, higher order chromatin organization, hormone regulation, mitotic bookmarking

DOI of Published Version

10.1002/gcc.22731

Source

Genes Chromosomes Cancer. 2019 Jul;58(7):484-499. doi: 10.1002/gcc.22731. Epub 2019 Mar 15. Link to article on publisher's site

Comments

Full author list omitted for brevity. For the full list of authors, see article.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Genes, chromosomes and cancer

PubMed ID

30873710

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