University of Massachusetts Medical School Faculty Publications
Title
Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer
UMMS Affiliation
Division of Genes and Development, Department of Pediatrics; Department of Biochemistry and Molecular Pharmacology; Imbalzano Lab; Nickerson Lab
Publication Date
2019-07-01
Document Type
Article
Disciplines
Amino Acids, Peptides, and Proteins | Biochemistry, Biophysics, and Structural Biology | Cancer Biology | Cell Biology | Cells | Genetic Phenomena | Genetics and Genomics | Neoplasms
Abstract
Cells establish and sustain structural and functional integrity of the genome to support cellular identity and prevent malignant transformation. In this review, we present a strategic overview of epigenetic regulatory mechanisms including histone modifications and higher order chromatin organization (HCO) that are perturbed in breast cancer onset and progression. Implications for dysfunctions that occur in hormone regulation, cell cycle control, and mitotic bookmarking in breast cancer are considered, with an emphasis on epithelial-to-mesenchymal transition and cancer stem cell activities. The architectural organization of regulatory machinery is addressed within the contexts of translating cancer-compromised genomic organization to advances in breast cancer risk assessment, diagnosis, prognosis, and identification of novel therapeutic targets with high specificity and minimal off target effects.
Keywords
RUNX, breast cancer, cancer stem cells, epithelial to mesenchymal transition, higher order chromatin organization, hormone regulation, mitotic bookmarking
DOI of Published Version
10.1002/gcc.22731
Source
Genes Chromosomes Cancer. 2019 Jul;58(7):484-499. doi: 10.1002/gcc.22731. Epub 2019 Mar 15. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Genes, chromosomes and cancer
PubMed ID
30873710
Repository Citation
Fritz AJ, Nickerson JA, Imbalzano AN, Stein GS. (2019). Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1002/gcc.22731. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1635
Comments
Full author list omitted for brevity. For the full list of authors, see article.