University of Massachusetts Medical School Faculty Publications

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

2019-08-29

Document Type

Article Preprint

Disciplines

Amino Acids, Peptides, and Proteins | Biological Phenomena, Cell Phenomena, and Immunity | Cells | Fungi | Genetic Phenomena | Immunology and Infectious Disease | Nervous System Diseases | Pathogenic Microbiology | Virus Diseases

Abstract

Cryptococcus neoformans can cause fatal meningoencephalitis in patients with AIDS or other immune-compromising conditions. Current antifungals are suboptimal to treat this disease, therefore, novel targets and new therapies are needed. Previously, we have shown that chitosan is a critical component of the cryptococcal cell wall, is required for survival in the mammalian host, and that chitosan deficiency results in rapid clearance from the mammalian host. We had also identified several specific proteins that were required for chitosan biosynthesis, and we hypothesize that screening for compounds that inhibit chitosan biosynthesis would identify additional genes/proteins that influence chitosan biosynthesis.

Keywords

Microbiology, Cryptococcus neoformans, chitosan, meningoencephalitis, AIDS, therapeutics, proteins, biosynthesis

Rights and Permissions

The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.

DOI of Published Version

10.1101/751172

Source

bioRxiv 751172; doi: https://doi.org/10.1101/751172. Link to preprint on bioRxiv service.

Journal/Book/Conference Title

bioRxiv

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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