Department of Medicine, Division of Infectious Diseases and Immunology
Amino Acids, Peptides, and Proteins | Biological Phenomena, Cell Phenomena, and Immunity | Cells | Fungi | Genetic Phenomena | Immunology and Infectious Disease | Nervous System Diseases | Pathogenic Microbiology | Virus Diseases
Cryptococcus neoformans can cause fatal meningoencephalitis in patients with AIDS or other immune-compromising conditions. Current antifungals are suboptimal to treat this disease, therefore, novel targets and new therapies are needed. Previously, we have shown that chitosan is a critical component of the cryptococcal cell wall, is required for survival in the mammalian host, and that chitosan deficiency results in rapid clearance from the mammalian host. We had also identified several specific proteins that were required for chitosan biosynthesis, and we hypothesize that screening for compounds that inhibit chitosan biosynthesis would identify additional genes/proteins that influence chitosan biosynthesis.
Microbiology, Cryptococcus neoformans, chitosan, meningoencephalitis, AIDS, therapeutics, proteins, biosynthesis
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The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.
DOI of Published Version
bioRxiv 751172; doi: https://doi.org/10.1101/751172. Link to preprint on bioRxiv service.
Maybruck, Brian T.; Lam, Woei C.; Specht, Charles A.; Ilagan, Ma Xenia G.; Donlin, Maureen J.; and Lodge, Jennifer K., "The aminoalkylindole, BML-190, negatively regulates chitosan synthesis via the cAMP/PKA1 pathway in Cryptococcus neoformans" (2019). University of Massachusetts Medical School Faculty Publications. 1628.
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