Mitochondrial Biogenesis: MitoCPR Resuscitates Import-Defective Mitochondria
Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network; School of Medicine; Senior Scholars Program
Amino Acids, Peptides, and Proteins | Cell Biology | Cells | Developmental Biology
Mitochondrial biogenesis requires the import of approximately 1,000 different proteins through a labyrinth of channels to reach the appropriate sub-organellar location. A new study now reports that, in response to stalled import complexes, an adaptive transcriptional response dubbed the mitoCPR is triggered to extract these stalled complexes into the cytosol for degradation.
DOI of Published Version
Curr Biol. 2018 Jun 4;28(11):R669-R671. doi: 10.1016/j.cub.2018.04.094. Link to article on publisher's site
Current biology : CB
Pires, Jacqueline and Haynes, Cole M., "Mitochondrial Biogenesis: MitoCPR Resuscitates Import-Defective Mitochondria" (2018). University of Massachusetts Medical School Faculty Publications. 1582.