University of Massachusetts Medical School Faculty Publications
Title
Mitochondrial Biogenesis: MitoCPR Resuscitates Import-Defective Mitochondria
UMMS Affiliation
Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network; School of Medicine; Senior Scholars Program
Publication Date
2018-06-04
Document Type
Article
Disciplines
Amino Acids, Peptides, and Proteins | Cell Biology | Cells | Developmental Biology
Abstract
Mitochondrial biogenesis requires the import of approximately 1,000 different proteins through a labyrinth of channels to reach the appropriate sub-organellar location. A new study now reports that, in response to stalled import complexes, an adaptive transcriptional response dubbed the mitoCPR is triggered to extract these stalled complexes into the cytosol for degradation.
DOI of Published Version
10.1016/j.cub.2018.04.094
Source
Curr Biol. 2018 Jun 4;28(11):R669-R671. doi: 10.1016/j.cub.2018.04.094. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Current biology : CB
PubMed ID
29870708
Repository Citation
Pires J, Haynes CM. (2018). Mitochondrial Biogenesis: MitoCPR Resuscitates Import-Defective Mitochondria. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1016/j.cub.2018.04.094. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1582
Comments
Jacqueline Pires participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.