University of Massachusetts Medical School Faculty Publications

Title

Mitochondrial Biogenesis: MitoCPR Resuscitates Import-Defective Mitochondria

UMMS Affiliation

Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network

Publication Date

2018-06-04

Document Type

Article

Disciplines

Amino Acids, Peptides, and Proteins | Cell Biology | Cells | Developmental Biology

Abstract

Mitochondrial biogenesis requires the import of approximately 1,000 different proteins through a labyrinth of channels to reach the appropriate sub-organellar location. A new study now reports that, in response to stalled import complexes, an adaptive transcriptional response dubbed the mitoCPR is triggered to extract these stalled complexes into the cytosol for degradation.

DOI of Published Version

10.1016/j.cub.2018.04.094

Source

Curr Biol. 2018 Jun 4;28(11):R669-R671. doi: 10.1016/j.cub.2018.04.094. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Current biology : CB

PubMed ID

29870708

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