University of Massachusetts Medical School Faculty Publications

UMMS Affiliation

Department of Microbiology and Physiological Systems; Department of Pediatrics; Department of Medicine, Division of Infectious Diseases and Immunology; Program in Bioinformatics and Integrative Biology

Publication Date

2014-09-30

Document Type

Article Preprint

Disciplines

Ecology and Evolutionary Biology | Immunology of Infectious Disease | Microbiology | Pathology | Virus Diseases | Viruses

Abstract

Human cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on the order of days or months. We describe the intrahost genetic diversity of the virus isolated from humans, and how this diversity contributes to HCMV spatiotemporal evolution. We propose mechanisms to explain the high levels of intrahost diversity and discuss how this new information may shed light on HCMV infection and pathogenesis.

Keywords

microbiology, evolutionary biology, Human cytomegalovirus, evolution, pathogenesis

Rights and Permissions

The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.

DOI of Published Version

10.1101/009571

Source

bioRxiv 009571; doi: https://doi.org/10.1101/009571. Link to preprint on bioRxiv service.

Related Resources

Now published in Current Opinion in Virology doi: 10.1016/j.coviro.2014.08.001

Journal/Book/Conference Title

bioRxiv

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.