Department of Microbiology and Physiological Systems; Department of Pediatrics; Department of Medicine, Division of Infectious Diseases and Immunology; Program in Bioinformatics and Integrative Biology
Ecology and Evolutionary Biology | Immunology of Infectious Disease | Microbiology | Pathology | Virus Diseases | Viruses
Human cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on the order of days or months. We describe the intrahost genetic diversity of the virus isolated from humans, and how this diversity contributes to HCMV spatiotemporal evolution. We propose mechanisms to explain the high levels of intrahost diversity and discuss how this new information may shed light on HCMV infection and pathogenesis.
microbiology, evolutionary biology, Human cytomegalovirus, evolution, pathogenesis
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The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.
DOI of Published Version
bioRxiv 009571; doi: https://doi.org/10.1101/009571. Link to preprint on bioRxiv service.
Now published in Current Opinion in Virology doi: 10.1016/j.coviro.2014.08.001
Renzette, Nicholas; Gibson, Laura L.; Jensen, Jeffrey D.; and Kowalik, Timothy F., "Human Cytomegalovirus Intrahost Evolution--A New Avenue for Understanding and Controlling Herpesvirus Infections" (2014). University of Massachusetts Medical School Faculty Publications. 1547.
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