University of Massachusetts Medical School Faculty Publications
UMMS Affiliation
Department of Pathology
Publication Date
2018-05-08
Document Type
Article Preprint
Disciplines
Bioinformatics | Genetic Phenomena | Hemic and Immune Systems | Immunopathology
Abstract
Studies in mouse have shed important light on human hematopoietic differentiation and disease. However, substantial differences between the two species often limit the translation of findings from mouse to human. Here, we compare modules of co-expressed genes in human and mouse immune cells based on compendia of genome-wide profiles. We show that the overall modular organization of the transcriptional program is conserved. We highlight modules of co-expressed genes in one species that dissolve or split in the other species. Many of the associated regulatory mechanisms - as reflected by computationally inferred trans regulators, or enriched cis-regulatory elements - are conserved between the species. Nevertheless, the degree of conservation in regulatory mechanism is lower than that of expression, suggesting that distinct regulation may underlie some of the conserved transcriptional responses.
Keywords
bioinformatics, mice, immune systems, transcriptional programs, genes
Rights and Permissions
The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.
DOI of Published Version
10.1101/286211
Source
bioRxiv 286211; doi: https://doi.org/10.1101/286211. Link to preprint on bioRxiv service.
Journal/Book/Conference Title
bioRxiv
Repository Citation
Shay T, Jojic V, Broad Institute of MIT and Harvard, Harvard Medical School, Stanford University, Broad Institute of MIT and Harvard, ImmGen Consortium, Narayan K, Sylvia KE, Kang J. (2018). Conservation and divergence in modules of the transcriptional programs of the human and mouse immune systems [preprint]. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1101/286211. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1535
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Included in
Bioinformatics Commons, Genetic Phenomena Commons, Hemic and Immune Systems Commons, Immunopathology Commons
Comments
Kavitha Narayan, Katelyn Sylvia and Joonsoo Kang are members of the ImmGen Consortium.