Department of Pathology
Bioinformatics | Genetic Phenomena | Hemic and Immune Systems | Immunopathology
Studies in mouse have shed important light on human hematopoietic differentiation and disease. However, substantial differences between the two species often limit the translation of findings from mouse to human. Here, we compare modules of co-expressed genes in human and mouse immune cells based on compendia of genome-wide profiles. We show that the overall modular organization of the transcriptional program is conserved. We highlight modules of co-expressed genes in one species that dissolve or split in the other species. Many of the associated regulatory mechanisms - as reflected by computationally inferred trans regulators, or enriched cis-regulatory elements - are conserved between the species. Nevertheless, the degree of conservation in regulatory mechanism is lower than that of expression, suggesting that distinct regulation may underlie some of the conserved transcriptional responses.
bioinformatics, mice, immune systems, transcriptional programs, genes
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The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.
DOI of Published Version
bioRxiv 286211; doi: https://doi.org/10.1101/286211. Link to preprint on bioRxiv service.
Shay, Tal; Jojic, Vladimir; Broad Institute of MIT and Harvard; Harvard Medical School; Stanford University; Broad Institute of MIT and Harvard; ImmGen Consortium; Narayan, Kavitha; Sylvia, Katelyn E.; and Kang, Joonso, "Conservation and divergence in modules of the transcriptional programs of the human and mouse immune systems" (2018). University of Massachusetts Medical School Faculty Publications. 1535.
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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.