University of Massachusetts Medical School Faculty Publications

UMMS Affiliation

Department of Neurobiology; Alkema Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Publication Date

2014-04-02

Document Type

Article Preprint

Disciplines

Neuroscience and Neurobiology | Systems Neuroscience

Abstract

A fundamental goal of systems neuroscience is to probe the dynamics of neural activity that drive behavior. Here we present an instrument to simultaneously manipulate neural activity via Channelrhodopsin, monitor neural response via GCaMP3, and observes behavior in freely moving C. elegans. We use the instrument to directly observe the relation between sensory stimuli, interneuron activity and locomotion in the mechanosensory circuit. Now published as: Front Neural Circuits 8:28, doi:10.3389/fncir.2014.00028

Keywords

optogenetics, systems neuroscience, calcium imaging, C. elegans, Channelrhodopsin, GCaMP3, neuroscience

Rights and Permissions

The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC 4.0 International license.

DOI of Published Version

10.1101/000943

Source

bioRxiv 000943; doi: https://doi.org/10.1101/000943. Link to preprint on bioRxiv service.

Related Resources

Now published in Front Neural Circuits 8:28, doi:10.3389/fncir.2014.00028

Journal/Book/Conference Title

bioRxiv

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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