University of Massachusetts Medical School Faculty Publications

UMMS Affiliation

Department of Neurobiology; Alkema Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Publication Date


Document Type

Article Preprint


Neuroscience and Neurobiology | Systems Neuroscience


A fundamental goal of systems neuroscience is to probe the dynamics of neural activity that drive behavior. Here we present an instrument to simultaneously manipulate neural activity via Channelrhodopsin, monitor neural response via GCaMP3, and observes behavior in freely moving C. elegans. We use the instrument to directly observe the relation between sensory stimuli, interneuron activity and locomotion in the mechanosensory circuit. Now published as: Front Neural Circuits 8:28, doi:10.3389/fncir.2014.00028


optogenetics, systems neuroscience, calcium imaging, C. elegans, Channelrhodopsin, GCaMP3, neuroscience

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The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC 4.0 International license.

DOI of Published Version



bioRxiv 000943; doi: Link to preprint on bioRxiv service.

Related Resources

Now published in Front Neural Circuits 8:28, doi:10.3389/fncir.2014.00028

Journal/Book/Conference Title


Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License



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