University of Massachusetts Medical School Faculty Publications
UMMS Affiliation
Program in Molecular Medicine
Publication Date
2018-05-16
Document Type
Article Preprint
Disciplines
Biochemical Phenomena, Metabolism, and Nutrition | Cell Biology | Cellular and Molecular Physiology | Genetic Phenomena | Lipids
Abstract
White adipose tissue (WAT) secretes factors to communicate with other metabolic organs to maintain energy homeostasis. We previously reported that perturbation of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) causes expansion of sympathetic neurons within white adipose tissue (WAT) and the appearance of beige adipocytes. Here we report evidence that white adipocyte DNL activity is also coupled to neuronal regulation and thermogenesis in brown adipose tissue (BAT). Induced deletion of FASN in all adipocytes in mature mice (iAdFASNKO) enhanced sympathetic innervation and neuronal activity as well as UCP1 expression in both WAT and BAT. In contrast, selective ablation of FASN in brown adipocytes of mice (iUCP1FASNKO) failed to modulate sympathetic innervation and the thermogenic program in BAT. Surprisingly, DNL in brown adipocytes was also dispensable in maintaining euthermia when UCP1FASNKO mice were cold-exposed. These results indicate that DNL in white adipocytes influences long distance signaling to BAT, which can modify BAT sympathetic innervation and expression of genes involved in thermogenesis.
Keywords
Brown Adipose Activity, White Adipocyte Lipogenesis, White adipose tissue, fatty acid synthase, thermogenesis, mice, cell biology
Rights and Permissions
The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.
DOI of Published Version
10.1101/324160
Source
bioRxiv 324160; doi: https://doi.org/10.1101/324160. Link to preprint on bioRxiv service
Journal/Book/Conference Title
bioRxiv
Repository Citation
Guilherme AL, Pedersen DJ, Henriques F, Bedard AH, Henchey E, Kelly M, Rahmouni K, Morgan DA, Czech MP. (2018). Neuronal Modulation of Brown Adipose Activity Through Perturbation of White Adipocyte Lipogenesis [preprint]. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1101/324160. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1496
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Cell Biology Commons, Cellular and Molecular Physiology Commons, Genetic Phenomena Commons, Lipids Commons