Program in Molecular Medicine
Biochemical Phenomena, Metabolism, and Nutrition | Cell Biology | Cellular and Molecular Physiology | Genetic Phenomena | Lipids
White adipose tissue (WAT) secretes factors to communicate with other metabolic organs to maintain energy homeostasis. We previously reported that perturbation of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) causes expansion of sympathetic neurons within white adipose tissue (WAT) and the appearance of beige adipocytes. Here we report evidence that white adipocyte DNL activity is also coupled to neuronal regulation and thermogenesis in brown adipose tissue (BAT). Induced deletion of FASN in all adipocytes in mature mice (iAdFASNKO) enhanced sympathetic innervation and neuronal activity as well as UCP1 expression in both WAT and BAT. In contrast, selective ablation of FASN in brown adipocytes of mice (iUCP1FASNKO) failed to modulate sympathetic innervation and the thermogenic program in BAT. Surprisingly, DNL in brown adipocytes was also dispensable in maintaining euthermia when UCP1FASNKO mice were cold-exposed. These results indicate that DNL in white adipocytes influences long distance signaling to BAT, which can modify BAT sympathetic innervation and expression of genes involved in thermogenesis.
Brown Adipose Activity, White Adipocyte Lipogenesis, White adipose tissue, fatty acid synthase, thermogenesis, mice, cell biology
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DOI of Published Version
bioRxiv 324160; doi: https://doi.org/10.1101/324160. Link to preprint on bioRxiv service
Guilherme, Adilson L.; Pedersen, David J.; Henriques, Felipe; Bedard, Alexander H.; Henchey, Elizabeth; Kelly, Mark; Rahmouni, Kamal; Morgan, Donald A.; and Czech, Michael P., "Neuronal Modulation of Brown Adipose Activity Through Perturbation of White Adipocyte Lipogenesis" (2018). University of Massachusetts Medical School Faculty Publications. 1496.
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