Neuronal Modulation of Brown Adipose Activity Through Perturbation of White Adipocyte Lipogenesis [preprint]
Authors
Guilherme, Adilson L.Pedersen, David J.
Henriques, Felipe
Bedard, Alexander H.
Henchey, Elizabeth
Kelly, Mark
Rahmouni, Kamal
Morgan, Donald A.
Czech, Michael P.
UMass Chan Affiliations
Program in Molecular MedicineDocument Type
PreprintPublication Date
2018-05-16Keywords
Brown Adipose ActivityWhite Adipocyte Lipogenesis
White adipose tissue
fatty acid synthase
thermogenesis
mice
cell biology
Biochemical Phenomena, Metabolism, and Nutrition
Cell Biology
Cellular and Molecular Physiology
Genetic Phenomena
Lipids
Metadata
Show full item recordAbstract
White adipose tissue (WAT) secretes factors to communicate with other metabolic organs to maintain energy homeostasis. We previously reported that perturbation of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) causes expansion of sympathetic neurons within white adipose tissue (WAT) and the appearance of beige adipocytes. Here we report evidence that white adipocyte DNL activity is also coupled to neuronal regulation and thermogenesis in brown adipose tissue (BAT). Induced deletion of FASN in all adipocytes in mature mice (iAdFASNKO) enhanced sympathetic innervation and neuronal activity as well as UCP1 expression in both WAT and BAT. In contrast, selective ablation of FASN in brown adipocytes of mice (iUCP1FASNKO) failed to modulate sympathetic innervation and the thermogenic program in BAT. Surprisingly, DNL in brown adipocytes was also dispensable in maintaining euthermia when UCP1FASNKO mice were cold-exposed. These results indicate that DNL in white adipocytes influences long distance signaling to BAT, which can modify BAT sympathetic innervation and expression of genes involved in thermogenesis.Source
bioRxiv 324160; doi: https://doi.org/10.1101/324160. Link to preprint on bioRxiv service
DOI
10.1101/324160Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29265Rights
The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1101/324160
Scopus Count
Collections
Except where otherwise noted, this item's license is described as The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.