University of Massachusetts Medical School Faculty Publications

UMMS Affiliation

UMass Metabolic Network; Department of Molecular, Cell, and Cancer Biology

Publication Date

2-9-2018

Document Type

Article

Disciplines

Cell Biology | Cellular and Molecular Physiology | Molecular Biology

Abstract

The mitochondrial network is not only required for the production of energy, essential cofactors and amino acids, but also serves as a signaling hub for innate immune and apoptotic pathways. Multiple mechanisms have evolved to identify and combat mitochondrial dysfunction to maintain the health of the organism. One such pathway is the mitochondrial unfolded protein response (UPR(mt)), which is regulated by the mitochondrial import efficiency of the transcription factor ATFS-1 in C. elegans and potentially orthologous transcription factors in mammals (ATF4, ATF5, CHOP). Upon mitochondrial dysfunction, import of ATFS-1 into mitochondria is reduced, allowing it to be trafficked to the nucleus where it promotes the expression of genes that promote survival and recovery of the mitochondrial network. Here, we discuss recent findings underlying UPR(mt) signal transduction and how this adaptive transcriptional response may interact with other mitochondrial stress response pathways.

Keywords

mitochondrial UPR, ISR, stress response, proteostasis

Rights and Permissions

Copyright © 2018 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

DOI of Published Version

10.1038/cr.2018.16

Source

Cell Res. 2018 Mar;28(3):281-295. doi: 10.1038/cr.2018.16. Epub 2018 Feb 9. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Cell research

PubMed ID

29424373

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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