UMass Metabolic Network; Department of Molecular, Cell, and Cancer Biology
Amino Acids, Peptides, and Proteins | Cell Biology | Cellular and Molecular Physiology | Genetic Phenomena | Molecular Biology
The mitochondrial network is not only required for the production of energy, essential cofactors and amino acids, but also serves as a signaling hub for innate immune and apoptotic pathways. Multiple mechanisms have evolved to identify and combat mitochondrial dysfunction to maintain the health of the organism. One such pathway is the mitochondrial unfolded protein response (UPR(mt)), which is regulated by the mitochondrial import efficiency of the transcription factor ATFS-1 in C. elegans and potentially orthologous transcription factors in mammals (ATF4, ATF5, CHOP). Upon mitochondrial dysfunction, import of ATFS-1 into mitochondria is reduced, allowing it to be trafficked to the nucleus where it promotes the expression of genes that promote survival and recovery of the mitochondrial network. Here, we discuss recent findings underlying UPR(mt) signal transduction and how this adaptive transcriptional response may interact with other mitochondrial stress response pathways.
mitochondrial UPR, ISR, stress response, proteostasis
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DOI of Published Version
Cell Res. 2018 Mar;28(3):281-295. doi: 10.1038/cr.2018.16. Epub 2018 Feb 9. Link to article on publisher's site
Melber A, Haynes CM. (2018). UPR(mt) regulation and output: a stress response mediated by mitochondrial-nuclear communication. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1038/cr.2018.16. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1470
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.