University of Massachusetts Medical School Faculty Publications

Title

Making fair comparisons in pregnancy medication safety studies: An overview of advanced methods for confounding control

UMMS Affiliation

Department of Quantitative Health Sciences

Publication Date

2017-10-17

Document Type

Article

Disciplines

Maternal and Child Health | Pharmaceutical Preparations | Women's Health

Abstract

Understanding the safety of medication use during pregnancy relies on observational studies: However, confounding in observational studies poses a threat to the validity of estimates obtained from observational data. Newer methods, such as marginal structural models and propensity calibration, have emerged to deal with complex confounding problems, but these methods have seen limited uptake in the pregnancy medication literature. In this article, we provide an overview of newer advanced methods for confounding control and show how these methods are relevant for pregnancy medication safety studies.

DOI of Published Version

10.1002/pds.4336

Source

Pharmacoepidemiol Drug Saf. 2017 Oct 17. doi: 10.1002/pds.4336. [Epub ahead of print] Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Pharmacoepidemiology and drug safety

PubMed ID

29044735

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