Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus
Department of Medicine, Division of Preventive and Behavioral Medicine
Immunology and Infectious Disease | Virus Diseases
HIV-1-specific broadly neutralizing antibodies (bNAbs) can protect rhesus monkeys against simian-human immunodeficiency virus (SHIV) challenge. However, the site of antibody interception of virus and the mechanism of antibody-mediated protection remain unclear. We administered a fully protective dose of the bNAb PGT121 to rhesus monkeys and challenged them intravaginally with SHIV-SF162P3. In PGT121-treated animals, we detected low levels of viral RNA and viral DNA in distal tissues for seven days following challenge. Viral RNA-positive tissues showed transcriptomic changes indicative of innate immune activation, and cells from these tissues initiated infection after adoptive transfer into naive hosts. These data demonstrate that bNAb-mediated protection against a mucosal virus challenge can involve clearance of infectious virus in distal tissues.
DOI of Published Version
Science. 2016 Sep 2;353(6303):1045-1049. Epub 2016 Aug 18. Link to article on publisher's site
Science (New York, N.Y.)
Liu, Jinyan; Li, Wenjun; and Barouch, Dan H., "Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus" (2016). University of Massachusetts Medical School Faculty Publications. 1372.