UMass Chan Medical School Faculty Publications

Title

Does EBV alter the pathogenesis of malaria

UMMS Affiliation

Program in Molecular Medicine

Publication Date

2015-09-01

Document Type

Article

Disciplines

Animal Experimentation and Research | Epidemiology | Hemic and Immune Systems | Immunopathology | Parasitic Diseases | Parasitology | Pathology | Viruses

Abstract

Plasmodium falciparum infections have been implicated in immune deficiencies resulting in ineffective control of Epstein-Barr virus, thereby increasing the risk of endemic Burkitt lymphoma in children. However, the impact of Epstein-Barr virus infections on the development of immunity to P. falciparum has not been studied in depth. In this review, we examine novel findings from animal co-infection models and human immuno-epidemiologic studies to speculate on the impact of acute gammaherpesvirus co-infection on malarial disease severity. Children are often concurrently or sequentially infected with multiple pathogens, and this has implications for understanding the development of protective immunity as well as in the evaluation of vaccine efficacy.

Keywords

animal models, co‐infection, epidemiologic studies, immunity

DOI of Published Version

10.1111/pim.12212

Source

Parasite Immunol. 2015 Sep;37(9):433-45. doi: 10.1111/pim.12212. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Parasite immunology

PubMed ID

26121587

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