University of Massachusetts Medical School Faculty Publications
Title
Regulation of postsynaptic retrograde signaling by presynaptic exosome release
UMMS Affiliation
Department of Neurobiology; Budnik Lab; Yoshihara Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Publication Date
2013-03-20
Document Type
Article
Subjects
Animals; Animals, Genetically Modified; Drosophila; Drosophila Proteins; Exosomes; Neuromuscular Junction; Presynaptic Terminals; Signal Transduction; Synapses; Synaptic Potentials; Synaptotagmins
Disciplines
Developmental Neuroscience | Molecular and Cellular Neuroscience
Abstract
Retrograde signals from postsynaptic targets are critical during development and plasticity of synaptic connections. These signals serve to adjust the activity of presynaptic cells according to postsynaptic cell outputs and to maintain synaptic function within a dynamic range. Despite their importance, the mechanisms that trigger the release of retrograde signals and the role of presynaptic cells in this signaling event are unknown. Here we show that a retrograde signal mediated by Synaptotagmin 4 (Syt4) is transmitted to the postsynaptic cell through anterograde delivery of Syt4 via exosomes. Thus, by transferring an essential component of retrograde signaling through exosomes, presynaptic cells enable retrograde signaling.
DOI of Published Version
10.1016/j.neuron.2013.01.013
Source
Neuron. 2013 Mar 20;77(6):1039-46. doi: 10.1016/j.neuron.2013.01.013. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Neuron
PubMed ID
23522040
Repository Citation
Korkut, Ceren; Li, Yihang; Koles, Kate; Brewer, Cassandra; Ashley, James A.; Yoshihara, Motojiro; and Budnik, Vivian, "Regulation of postsynaptic retrograde signaling by presynaptic exosome release" (2013). University of Massachusetts Medical School Faculty Publications. 134.
https://escholarship.umassmed.edu/faculty_pubs/134
Comments
Authors Korkut, Li, and Ashley are doctoral students in the Neuroscience Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.