University of Massachusetts Medical School Faculty Publications


Association of labor induction or stimulation with infant mortality in women with failed versus successful trial of labor after prior cesarean

UMMS Affiliation

Department of Quantitative Health Sciences

Publication Date


Document Type



Maternal and Child Health | Obstetrics and Gynecology | Women's Health


Objective: To compare infant mortality rates among women with a failed versus successful trial of labor after cesarean (TOLAC) following labor induction or stimulation.

Study design: Using US linked birth and infant death cohort data (2000-2004), we identified women who delivered non-anomalous singleton births at 34-41 weeks with TOLAC whose labors were induced or stimulated. Multivariable log-binomial regression models were fitted to estimate the association between TOLAC success and infant mortality.

Results: Of the 164,113 women who underwent TOLAC, 41% were unsuccessful. After adjustment for potential confounding factors, a failed TOLAC was associated with a 1.4 fold (95% confidence interval [CI] 1.1, 1.7) increased risk of infant mortality.

Conclusions: Among women undergoing labor induction or stimulation, a failed TOLAC is associated with higher likelihood of infant mortality.

DOI of Published Version



J Matern Fetal Neonatal Med. 2013 Aug;26(12):1162-5. doi: 10.3109/14767058.2013.777700. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

The journal of maternal-fetal and neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

PubMed ID