UMass Chan Medical School Faculty Publications


Comparison of control fasting plasma glucose of exercise-only versus exercise-diet among a pre-diabetic population: a meta-analysis

UMMS Affiliation

Division of Preventive and Behavioral Medicine, Department of Medicine

Publication Date


Document Type



Dietetics and Clinical Nutrition | Human and Clinical Nutrition


BACKGROUND/OBJECTIVES: Exercise is considered a protective factor in the prevention of type 2 diabetes, although its role as a sole treatment for pre-diabetes remains unknown. The present meta-analysis compared the effect of exercise-only with exercise-diet interventions on plasma glucose levels among a pre-diabetic population.

SUBJECTS/METHODS: A literature search was conducted using PubMed, EMBASE and Cochrane databases. The Cochrane Collaboration tool was used to assess the quality of each trial. Two reviewers independently performed quality assessment of all included articles. A random effects model was used to calculate the pooled effect.

RESULTS: A total of 4021 participants from 12 studies were included in this meta-analysis, 2045 of them were in the intervention group and 1976 were in the control group. Compared with the exercise-only interventions, the exercise-diet interventions showed a significant effect on decreasing fasting plasma glucose (FPG) levels, with a weighted mean difference (WMD) =-0.22 mmol/l, 95% confidence interval (CI): -0.25, -0.18 (Z=12.06, P 0.05). According to the intervention periods, the pooled effect in the 2-year group was the highest, and its WMD (95% CI) was -0.24 mmol/l (-0.43,-0.05). The pooled effects were statistically significant among the elderly and those of American and European descent, with WMD (95% CI) being -0.19 mmol/l (95% CI: -0.22, -0.15), -0.17 mmol/l (-0.21,-0.12) and -0.22 mmol/l (-0.27, -0.17), respectively.

CONCLUSIONS: Evidence from published trials indicates that exercise-diet interventions showed a significant effect on decreasing FPG levels.

DOI of Published Version



Eur J Clin Nutr. 2016 Apr;70(4):424-30. doi: 10.1038/ejcn.2015.128. Epub 2015 Sep 2. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

European journal of clinical nutrition

PubMed ID