University of Massachusetts Medical School Faculty Publications
UMMS Affiliation
Department of Medicine, Division of Preventive and Behavioral Medicine
Publication Date
2017-05-09
Document Type
Article Postprint
Disciplines
Clinical Epidemiology | Dietetics and Clinical Nutrition | Epidemiology | Neoplasms | Women's Health
Abstract
We examined the associations between changes in dietary inflammatory potential and risk of colorectal cancer (CRC) in 87,042 postmenopausal women recruited from 1993-1998 into the Women's Health Initiative. Food frequency questionnaire data were used to compute patterns of change in dietary inflammatory index (DII) scores and cumulative average DII scores over 3 years. Cox regression models were used to estimate hazard ratios for CRC risk. After a median 16.2 years follow-up, 1,038 CRC cases were diagnosed. DII changes were not substantially associated with overall CRC, but proximal colon cancer risk was higher in the pro-inflammatory change DII compared to the anti-inflammatory stable DII groups (hazard ratio = 1.32; 95% confidence interval: 1.01, 1.74). Among non-users of nonsteroidal anti-inflammatory drugs (NSAID) (Pinteraction = 0.055) the pro-inflammatory stable DII group was at increased risk of overall CRC and proximal colon cancer. Also among non-users of NSAID, risks of overall CRC, colon cancer, and proximal colon cancer were higher in the highest quintile compared to the lowest cumulative average DII quintile (65%, 61%, and 91% increased risk, respectively). Dietary changes towards, or a history of, pro-inflammatory diets are associated with an elevated risk of colon cancer, particularly for proximal colon cancer and among non-users of NSAID.
Keywords
Women's Health Initiative, colorectal cancer, dietary patterns, inflammation
Rights and Permissions
Authors' version posted after 12 months as allowed by the publisher's author rights policy at https://academic.oup.com/journals/pages/access_purchase/rights_and_permissions/self_archiving_policy_b.
DOI of Published Version
10.1093/aje/kwx115
Source
Am J Epidemiol. 2017 May 9. doi: 10.1093/aje/kwx115. Link to article on publisher's site.
Related Resources
Journal/Book/Conference Title
American journal of epidemiology
PubMed ID
28486621
Repository Citation
Tabung, Fred K.; Steck, Susan E.; Ma, Yunsheng; Liese, Angela D.; Zhang, Jiajia; Lane, Dorothy S.; Ho, Gloria Y. F; Hou, Lifang; Snetselaar, Linda; Ockene, Judith K.; and Hebert, James R., "Changes in the inflammatory potential of diet over time and risk of colorectal cancer in postmenopausal women" (2017). University of Massachusetts Medical School Faculty Publications. 1275.
https://escholarship.umassmed.edu/faculty_pubs/1275
Included in
Clinical Epidemiology Commons, Dietetics and Clinical Nutrition Commons, Epidemiology Commons, Neoplasms Commons, Women's Health Commons
Comments
This is a pre-copyedited, author-produced version of an article accepted for publication in American Journal of Epidemiology following peer review.