University of Massachusetts Medical School Faculty Publications
Title
Translational control of cell growth and malignancy by the CPEBs
UMMS Affiliation
Program in Molecular Medicine
Publication Date
2013-4
Document Type
Article
Subjects
Animals; Cell Aging; Cell Cycle; Cell Proliferation; Humans; *Neoplasms; Protein Biosynthesis; RNA, Messenger; RNA-Binding Proteins; Transcription Factors; mRNA Cleavage and Polyadenylation Factors
Disciplines
Cancer Biology | Cell Biology | Molecular Biology | Molecular Genetics
Abstract
The cytoplasmic polyadenylation element binding proteins (CPEBs) associate with specific sequences in mRNA 3' untranslated regions to promote translation. They do so by inducing cytoplasmic polyadenylation, which requires specialized poly(A) polymerases. Aberrant expression of these proteins correlates with certain types of cancer, indicating that cytoplasmic RNA 3' end processing is important in the control of growth. Several CPEB-regulated mRNAs govern cell cycle progression, regulate senescence, establish cell polarity, and promote tumorigenesis and metastasis. In this Opinion article, we discuss the emerging evidence that indicates a key role for the CPEBs in cancer biology.
DOI of Published Version
10.1038/nrc3485
Source
Nat Rev Cancer. 2013 Apr;13(4):283-90. doi: 10.1038/nrc3485. Epub 2013 Feb 28. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Nature reviews. Cancer
PubMed ID
23446545
Repository Citation
D'Ambrogio, Andrea; Nagaoka, Kentaro; and Richter, Joel D., "Translational control of cell growth and malignancy by the CPEBs" (2013). University of Massachusetts Medical School Faculty Publications. 122.
https://escholarship.umassmed.edu/faculty_pubs/122