UMass Chan Medical School Faculty Publications
Title
Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent
UMMS Affiliation
Department of Medicine, Division of Rheumatology; Department of Medicine, Division of Infectious Diseases and Immunology; Program in Innate Immunity
Publication Date
2017-01-01
Document Type
Article
Disciplines
Cell Biology | Immune System Diseases | Immunology and Infectious Disease
Abstract
Both endosomal and cytosolic-nucleic acid-sensing receptors can detect endogenous ligands and promote autoimmunity and autoinflammation. These responses involve a complex interplay among and between the cytosolic and endosomal sensors involving both hematopoietic and radioresistant cells. Cytosolic sensors directly promote inflammatory responses through the production of type I IFNs and proinflammatory cytokines. Inflammation-associated tissue damage can further promote autoimmune responses indirectly, as receptor-mediated internalization of the resulting cell debris can activate endosomal Toll-like receptors (TLR). Both endosomal and cytosolic receptors can also negatively regulate inflammatory responses. A better understanding of the factors and pathways that promote and constrain autoimmune diseases will have important implications for the development of agonists and antagonists that modulate these pathways.
Keywords
Toll-like receptor, autoantibody, cGAS, systemic lupus erythematosus
DOI of Published Version
10.1189/jlb.3MR0316-115R
Source
J Leukoc Biol. 2017 Jan;101(1):121-126. doi: 10.1189/jlb.3MR0316-115R. Epub 2016 Aug 16. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Journal of leukocyte biology
PubMed ID
27531928
Repository Citation
Pawaria S, Sharma S, Baum R, Nundel K, Busto P, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. (2017). Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent. UMass Chan Medical School Faculty Publications. https://doi.org/10.1189/jlb.3MR0316-115R. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1218