University of Massachusetts Medical School Faculty Publications
Title
Generation of voxelized breast phantoms from surgical mastectomy specimens
UMMS Affiliation
Department of Radiology
Publication Date
2013-4
Document Type
Article
Subjects
Breast; Phantoms, Imaging
Disciplines
Analytical, Diagnostic and Therapeutic Techniques and Equipment | Bioimaging and Biomedical Optics | Biomedical Devices and Instrumentation | Radiology
Abstract
PURPOSE: In the research and development of dedicated tomographic breast imaging systems, digital breast object models, also known as digital phantoms, are useful tools. While various digital breast phantoms do exist, the purpose of this study was to develop a realistic high-resolution model suitable for simulating three-dimensional (3D) breast imaging modalities. The primary goal was to design a model capable of producing simulations with realistic breast tissue structure.
METHODS: The methodology for generating an ensemble of digital breast phantoms was based on imaging surgical mastectomy specimens using a benchtop, cone-beam computed tomography system. This approach allowed low-noise, high-resolution projection views of the mastectomy specimens at each angular position. Reconstructions of these projection sets were processed using correction techniques and diffusion filtering prior to segmentation into breast tissue types in order to generate phantoms.
RESULTS: Eight compressed digital phantoms and 20 uncompressed phantoms from which an additional 96 pseudocompressed digital phantoms with voxel dimensions of 0.2 mm(3) were generated. Two distinct tissue classification models were used in forming breast phantoms. The binary model classified each tissue voxel as either adipose or fibroglandular. A multivalue scaled model classified each tissue voxel as percentage of adipose tissue (range 1%-99%). Power spectral analysis was performed to compare simulated reconstructions using the breast phantoms to the original breast specimen reconstruction, and fits were observed to be similar.
CONCLUSIONS: The digital breast phantoms developed herein provide a high-resolution anthropomorphic model of the 3D uncompressed and compressed breast that are suitable for use in evaluating and optimizing tomographic breast imaging modalities. The authors believe that other research groups might find the phantoms useful, and therefore they offer to make them available for wider use.
DOI of Published Version
10.1118/1.4795758
Source
Med Phys. 2013 Apr;40(4):041915. doi: 10.1118/1.4795758. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Medical physics
PubMed ID
23556909
Repository Citation
O'Connor, J. Michael; Das, Mini; Dider, Clay S.; Mahd, Mufeed; and Glick, Stephen J., "Generation of voxelized breast phantoms from surgical mastectomy specimens" (2013). University of Massachusetts Medical School Faculty Publications. 120.
https://escholarship.umassmed.edu/faculty_pubs/120