Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice
Department of Medicine, Division of Gastroenterology; Graduate School of Biomedical Sciences, Translational Science Program; UMass Metabolic Network
Cell Biology | Cellular and Molecular Physiology | Digestive System Diseases | Gastroenterology | Hepatology
BACKGROUND and AIMS: Inflammation and impaired hepatocyte regeneration contribute to liver failure in alcoholic hepatitis (AH). Interleukin (IL)-1 is a key inflammatory cytokine in the pathobiology of AH. The role of IL-1 in liver regeneration in the recovery phase of alcohol-induced liver injury is unknown.
METHODS: Here we tested IL-1 receptor antagonist to block IL-1 signaling in a mouse model of acute-on-chronic liver injury on liver inflammation and hepatocyte regeneration in AH.
RESULTS: We observed that inhibition of IL-1 signaling decreased liver inflammation, neutrophil infiltration, enhanced regeneration of hepatocytes, and resulted in increased rate of recovery from liver injury in AH.
CONCLUSION: Our novel findings suggest that IL-1 drives sustained liver inflammation and impaired hepatocyte regeneration even after cessation of ethanol exposure.
alcoholic liver disease, interleukin 1, interleukin 1 receptor antagonist, liver regeneration
DOI of Published Version
Liver Int. 2017 Mar 26. doi: 10.1111/liv.13430. Link to article on publisher's site
Liver international : official journal of the International Association for the Study of the Liver
Iracheta-Vellve, Arvin; Petrasek, Jan; Gyongyosi, Benedek; Bala, Shashi; Csak, Timea; Kodys, Karen; and Szabo, Gyongyi, "Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice" (2017). University of Massachusetts Medical School Faculty Publications. 1194.