University of Massachusetts Medical School Faculty Publications
UMMS Affiliation
Department of Orthopedics and Physical Rehabilitation
Publication Date
2017-04-01
Document Type
Article
Disciplines
Musculoskeletal Diseases | Rheumatology
Abstract
Psoriatic arthritis (PsA) is a chronic condition characterized by a diverse set of symptoms, from swollen joints to nail disease to skin disease. A variety of treatment options are available, including tumor necrosis factor inhibitors (TNFis). Little is known about treatment persistence in patients with PsA who initiate TNFi therapy, with and without prior biologic use. This study assessed persistence in these subgroups of patients with PsA and identified factors associated with persistence. This retrospective study utilized data from the Corrona registry of patients with PsA-with or without prior biologic experience-who initiated TNFi therapy between October 1, 2002, and March 21, 2013. Kaplan-Meier curves estimated median time to nonpersistence (discontinuation or switch to another biologic). Cox proportional hazards models identified factors associated with TNFi nonpersistence. A total of 1241 TNFi initiations were identified: 549 by biologic-naive and 692 by biologic-experienced patients. Through 4 years of follow-up, more biologic-naive than biologic-experienced patients remained persistent. Biologic-naive patients had a greater mean time to nonpersistence compared with biologic-experienced patients: 32 vs 23 months (p = 0.0002). Moderate and high disease activities based on clinical disease activity index and disease duration were associated with persistence in both biologic-naive and biologic-experienced patients. Additionally, in the biologic-experienced patients, the number of prior medications and skin disease were associated with persistence. The majority of patients with PsA in this study were persistent with their TNFi therapy; biologic-naive patients had greater persistence compared with biologic-experienced patients. Predictors of persistence differed slightly between biologic-naive and biologic-experienced patients.
Keywords
Biologics, Disease severity, Persistence, Psoriatic arthritis, Tumor necrosis factor inhibitors
Rights and Permissions
© The Author(s) 2017.
DOI of Published Version
10.1007/s10067-017-3593-x
Source
Clin Rheumatol. 2017 Apr;36(4):895-901. doi: 10.1007/s10067-017-3593-x. Epub 2017 Mar 7. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Clinical rheumatology
PubMed ID
28271234
Repository Citation
Harrold, Leslie R.; Stolshek, Bradley S.; Rebello, Sabrina; Collier, David H.; Mutebi, Alex; Wade, Sally W.; Malley, Wendi; Greenberg, Jeffrey D.; and Etzel, Carol J., "Impact of prior biologic use on persistence of treatment in patients with psoriatic arthritis enrolled in the US Corrona registry" (2017). University of Massachusetts Medical School Faculty Publications. 1188.
https://escholarship.umassmed.edu/faculty_pubs/1188
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.