University of Massachusetts Medical School Faculty Publications
UMMS Affiliation
Department of Orthopedics and Physical Rehabilitation
Publication Date
3-23-2016
Document Type
Article
Disciplines
Musculoskeletal Diseases | Rheumatology
Abstract
OBJECTIVE: To describe patient preferences in selecting specific biologics and compare clinical response using patient reported outcomes (PROs) among patients with rheumatoid arthritis (RA) started on different anti-tumor necrosis factor (TNF) therapies.
METHODS: Participants were enrollees in Kaiser Permanente Northern California. Patients with RA who had at least two provider visits and started a new anti-TNF therapy from 10/2010-8/2011, were eligible for participation in this longitudinal study. Using a telephone survey, patient preferences in biologic selection and RAPID3, MDHAQ, and SF-12 scores were collected at baseline and at 6 months. Patient scores rating injection/infusion-site burning and stinging (ISBS) were collected at 6 months.
RESULTS: In all, 267 patients with RA responded to the baseline survey, of whom 57% preferred an injectable biologic, 22% preferred an infused biologic, and 21% had no preference. Motivation for injectable biologics was convenience (92%) and for infusion therapy was dislike or lack of self-efficacy for self-injection (16%). After 6 months of treatment with anti-TNF, 70% of the 177 patients who answered the ISBS question reported ISBS with the last dose; on a scale of 1 (none) to 10 (worst), 41% of these reported a score of 2-5; and 29% reported a score of 6-10. Adalimumab users experienced 3.2 times (95% confidence interval 1.2-8.6) the level of ISBS that etanercept users experienced. There were no significant differences in RAPID3, MDHAQ, or SF-12 scores between etanercept or adalimumab initiators.
CONCLUSION: Convenience and fear of self-injection were important considerations to patients selecting a biologic drug. Although more convenient, adalimumab associated with more ISBS than did etanercept, and this rate was higher than reported in clinical trials. At 6 months, PROs did not differ between etanercept and adalimumab users.
Rights and Permissions
Copyright © 2016 Navarro-Millán et al.
DOI of Published Version
10.1371/journal.pone.0149781
Source
PLoS One. 2016 Mar 23;11(3):e0149781. doi: 10.1371/journal.pone.0149781. eCollection 2016. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
PloS one
PubMed ID
27007811
Repository Citation
Navarro-Millan, Iris; Herrinton, Lisa J.; Chen, Lang; Harrold, Leslie R.; Liu, Liyan; and Curtis, Jeffrey R., "Comparative Effectiveness of Etanercept and Adalimumab in Patient Reported Outcomes and Injection-Related Tolerability" (2016). University of Massachusetts Medical School Faculty Publications. 1184.
https://escholarship.umassmed.edu/faculty_pubs/1184
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.