Immunology. An RNA twist to T(H)17 cells
Program in Innate Immunity; Division of Infectious Diseases and Immunology, Department of Medicine
Immunology and Infectious Disease
T helper lymphocytes play essential roles in the adaptive immune system. They come in distinct types defined by unique transcriptional programs that control their development and functions. Among these, T helper 17 (TH17) cells are important in protecting mucosal surfaces against fungal and bacterial infections. In addition, TH17 cells contribute to the pathogenesis of multiple autoimmune diseases (1). A recent study (2) adds yet another layer of complexity to the biology of these complex cells—an RNA helicase and a long noncoding RNA (lncRNA) that act together to control their effector functions.
DOI of Published Version
Science. 2016 Mar 4;351(6277):1032. doi: 10.1126/science.aaf4691. Link to article on publisher's site
Science (New York, N.Y.)
Atianand, Maninjay K. and Fitzgerald, Katherine A., "Immunology. An RNA twist to T(H)17 cells" (2016). University of Massachusetts Medical School Faculty Publications. 1150.