Immunology. An RNA twist to T(H)17 cells
Program in Innate Immunity; Division of Infectious Diseases and Immunology, Department of Medicine
Immunology and Infectious Disease
T helper lymphocytes play essential roles in the adaptive immune system. They come in distinct types defined by unique transcriptional programs that control their development and functions. Among these, T helper 17 (TH17) cells are important in protecting mucosal surfaces against fungal and bacterial infections. In addition, TH17 cells contribute to the pathogenesis of multiple autoimmune diseases (1). A recent study (2) adds yet another layer of complexity to the biology of these complex cells—an RNA helicase and a long noncoding RNA (lncRNA) that act together to control their effector functions.
DOI of Published Version
Science. 2016 Mar 4;351(6277):1032. doi: 10.1126/science.aaf4691. Link to article on publisher's site
Science (New York, N.Y.)
Atianand MK, Fitzgerald KA. (2016). Immunology. An RNA twist to T(H)17 cells. UMass Chan Medical School Faculty Publications. https://doi.org/10.1126/science.aaf4691. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1150