University of Massachusetts Medical School Faculty Publications
Title
No effect of adjunctive, repeated-dose intranasal insulin treatment on psychopathology and cognition in patients with schizophrenia
UMMS Affiliation
Department of Psychiatry
Publication Date
2013-4
Document Type
Article
Subjects
Schizophrenia; Insulin; Cognition; Psychopathology
Disciplines
Mental and Social Health | Mental Disorders | Psychiatry and Psychology | Therapeutics
Abstract
OBJECTIVE: This study examined the effect of adjunctive intranasal insulin therapy on psychopathology and cognition in patients with schizophrenia.
METHODS: Each subject had a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis of schizophrenia or schizoaffective disorder and been on stable antipsychotics for at least 1 month. In an 8-week randomized, double-blind, placebo-controlled study, subjects received either intranasal insulin (40 IU 4 times per day) or placebo. Psychopathology was assessed using the Positive and Negative Syndrome Scale and the Scale for Assessment of Negative Symptoms. A neuropsychological battery was used to assess cognitive performance. The assessment for psychopathology and cognition was conducted at baseline, week 4, and week 8.
RESULTS: A total of 45 subjects were enrolled in the study (21 in the insulin group and 24 in the placebo group). The mixed model analysis showed that there were no significant differences between the 2 groups at week 8 on various psychopathology and cognitive measures (P > 0.1).
CONCLUSIONS: Adjunctive therapy with intranasal insulin did not seem to be beneficial in improving schizophrenia symptoms or cognition in the present study. The implications for future studies were discussed.
DOI of Published Version
10.1097/JCP.0b013e31828701d0
Source
J Clin Psychopharmacol. 2013 Apr;33(2):226-30. doi: 10.1097/JCP.0b013e31828701d0. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Journal of clinical psychopharmacology
PubMed ID
23422397
Repository Citation
Fan, Xiaoduo; Liu, Emily; Freudenreich, Oliver; Copeland, Paul; Hayden, Douglas; Ghebremichael, Musie; Cohen, Bruce M.; Ongur, Dost; Goff, Donald C.; and Henderson, David C., "No effect of adjunctive, repeated-dose intranasal insulin treatment on psychopathology and cognition in patients with schizophrenia" (2013). University of Massachusetts Medical School Faculty Publications. 114.
https://escholarship.umassmed.edu/faculty_pubs/114