Title

No effect of adjunctive, repeated-dose intranasal insulin treatment on psychopathology and cognition in patients with schizophrenia

Authors

Xiaoduo Fan, University of Massachusetts Medical SchoolFollow
Emily Liu, Partners Community Healthcare, Inc.
Oliver Freudenreich, Harvard Medical School
Paul Copeland, Harvard Medical School
Douglas Hayden, Massachusetts General Hospital
Musie Ghebremichael, Harvard Medical School
Bruce M. Cohen, Harvard Medical School
Dost Ongur, Harvard Medical School
Donald C. Goff, New York University Medical School
David C. Henderson, Harvard Medical School

UMMS Affiliation

Department of Psychiatry

Publication Date

2013-4

Document Type

Article

Subjects

Schizophrenia; Insulin; Cognition; Psychopathology

Disciplines

Mental and Social Health | Mental Disorders | Psychiatry and Psychology | Therapeutics

Abstract

OBJECTIVE: This study examined the effect of adjunctive intranasal insulin therapy on psychopathology and cognition in patients with schizophrenia.

METHODS: Each subject had a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis of schizophrenia or schizoaffective disorder and been on stable antipsychotics for at least 1 month. In an 8-week randomized, double-blind, placebo-controlled study, subjects received either intranasal insulin (40 IU 4 times per day) or placebo. Psychopathology was assessed using the Positive and Negative Syndrome Scale and the Scale for Assessment of Negative Symptoms. A neuropsychological battery was used to assess cognitive performance. The assessment for psychopathology and cognition was conducted at baseline, week 4, and week 8.

RESULTS: A total of 45 subjects were enrolled in the study (21 in the insulin group and 24 in the placebo group). The mixed model analysis showed that there were no significant differences between the 2 groups at week 8 on various psychopathology and cognitive measures (P > 0.1).

CONCLUSIONS: Adjunctive therapy with intranasal insulin did not seem to be beneficial in improving schizophrenia symptoms or cognition in the present study. The implications for future studies were discussed.

DOI of Published Version

10.1097/JCP.0b013e31828701d0

Source

J Clin Psychopharmacol. 2013 Apr;33(2):226-30. doi: 10.1097/JCP.0b013e31828701d0. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Journal of clinical psychopharmacology

PubMed ID

23422397

Repository Citation

Fan X, Liu E, Freudenreich O, Copeland P, Hayden D, Ghebremichael M, Cohen BM, Ongur D, Goff DC, Henderson DC. (2013). No effect of adjunctive, repeated-dose intranasal insulin treatment on psychopathology and cognition in patients with schizophrenia. UMass Chan Medical School Faculty Publications. https://doi.org/10.1097/JCP.0b013e31828701d0. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/114