Multiple Healthful Dietary Patterns and Type 2 Diabetes in the Women's Health Initiative
Department of Quantitative Health Sciences; Department of Medicine, Division of Preventive and Behavioral Medicine; UMass Worcester Prevention Research Center
Clinical Epidemiology | Dietetics and Clinical Nutrition | Epidemiology | Women's Health
The relationship between various diet quality indices and risk of type 2 diabetes (T2D) remains unsettled. We compared associations of 4 diet quality indices--the Alternate Mediterranean Diet Index, Healthy Eating Index 2010, Alternate Healthy Eating Index 2010, and the Dietary Approaches to Stop Hypertension (DASH) Index--with reported T2D in the Women's Health Initiative, overall, by race/ethnicity, and with/without adjustment for overweight/obesity at enrollment (a potential mediator). This cohort (n = 101,504) included postmenopausal women without T2D who completed a baseline food frequency questionnaire from which the 4 diet quality index scores were derived. Higher scores on the indices indicated a better diet. Cox regression was used to estimate multivariate hazard ratios for T2D. Pearson coefficients for correlation among the indices ranged from 0.55 to 0.74. Follow-up took place from 1993 to 2013. During a median 15 years of follow-up, 10,815 incident cases of T2D occurred. For each diet quality index, a 1-standard-deviation higher score was associated with 10%-14% lower T2D risk (P < 0.001). Adjusting for overweight/obesity at enrollment attenuated but did not eliminate associations to 5%-10% lower risk per 1-standard-deviation higher score (P < 0.001). For all 4 dietary indices examined, higher scores were inversely associated with T2D overall and across racial/ethnic groups. Multiple forms of a healthful diet were inversely associated with T2D in these postmenopausal women.
Alternate Healthy Eating Index, Alternate Mediterranean Diet Index, Dietary Approaches to Stop Hypertension Index, Healthy Eating Index, dietary patterns, health disparities, type 2 diabetes, women's health
DOI of Published Version
Am J Epidemiol. 2016 Apr 1;183(7):622-33. doi: 10.1093/aje/kwv241. Epub 2016 Mar 2. Link to article on publisher's site
American journal of epidemiology
Cespedes, Elizabeth M.; Li, Wenjun; and Waring, Molly E., "Multiple Healthful Dietary Patterns and Type 2 Diabetes in the Women's Health Initiative" (2016). University of Massachusetts Medical School Faculty Publications. 1137.