University of Massachusetts Medical School Faculty Publications
Title
Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine
UMMS Affiliation
Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network
Publication Date
9-1-2016
Document Type
Article
Disciplines
Cancer Biology | Nanotechnology
Abstract
Metastasis, drug resistance and recurrence in cancer are regulated by the tumor microenvironment. This review describes recent advances in understanding how cancer cells respond to extracellular environmental cues via integrins, how to build engineered microenvironments to study these interactions in vitro and how nanomaterials can be used to detect and target tumor microenvironments.
DOI of Published Version
10.1016/j.drudis.2016.05.011
Source
Drug Discov Today. 2016 Sep;21(9):1489-94. doi: 10.1016/j.drudis.2016.05.011. Epub 2016 May 26. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Drug discovery today
PubMed ID
27238384
Repository Citation
Yoshii, Tatsuyuki; Geng, Yingying; Peyton, Shelly; Mercurio, Arthur M.; and Rotello, Vincent M., "Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine" (2016). University of Massachusetts Medical School Faculty Publications. 1103.
https://escholarship.umassmed.edu/faculty_pubs/1103