UMass Chan Medical School Faculty Publications


IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle

UMMS Affiliation

Program in Molecular Medicine; Department of Medicine, Division of Cardiovascular Medicine; UMass Metabolic Network

Publication Date


Document Type



Cellular and Molecular Physiology | Endocrinology | Endocrinology, Diabetes, and Metabolism


Altered energy balance and insulin resistance are important characteristics of aging. Skeletal muscle is a major site of glucose disposal, and the role of aging-associated inflammation in skeletal muscle insulin resistance remains unclear. To investigate, we examined glucose metabolism in 18-mo-old transgenic mice with muscle-specific overexpression of IL-10 (MIL10) and in wild-type mice during hyperinsulinemic-euglycemic clamping. Despite similar fat mass and energy balance, MIL10 mice were protected from aging-associated insulin resistance with significant increases in glucose infusion rates, whole-body glucose turnover, and skeletal muscle glucose uptake ( approximately 60%; P < 0.05), as compared to age-matched WT mice. This protective effect was associated with decreased muscle inflammation, but no changes in adipose tissue inflammation in aging MIL10 mice. These results demonstrate the importance of skeletal muscle inflammation in aging-mediated insulin resistance, and our findings further implicate a potential therapeutic role of anti-inflammatory cytokine in the treatment of aging-mediated insulin resistance.


cytokines, interleukins, aging, type 2 diabetes, glucose metabolism

DOI of Published Version



FASEB J. 2016 Nov 3. pii: fj.201600832R. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

PubMed ID