University of Massachusetts Medical School Faculty Publications
Title
GBPs take AIM at Francisella
UMMS Affiliation
Program in Innate Immunity; Department of Medicine, Division of Infectious Diseases and Immunology
Publication Date
5-1-2015
Document Type
Article
Disciplines
Immunity
Abstract
Guanylate-binding proteins (GBPs) induced by type I interferon signaling cause lysis ofFrancisella bacteria that have reached the host-cell cytosol. The liberated bacterial DNA is then sensed by the cytosolic AIM2 inflammasome, which activates caspase-1 and leads to pyroptotic cell death.
DOI of Published Version
10.1038/ni.3144
Source
Nat Immunol. 2015 May;16(5):443-4. doi: 10.1038/ni.3144. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Nature immunology
PubMed ID
25898190
Repository Citation
Fitzgerald, Katherine A. and Rathinam, Vijay A. K., "GBPs take AIM at Francisella" (2015). University of Massachusetts Medical School Faculty Publications. 1001.
https://escholarship.umassmed.edu/faculty_pubs/1001