GBPs take AIM at Francisella
Program in Innate Immunity; Department of Medicine, Division of Infectious Diseases and Immunology
Guanylate-binding proteins (GBPs) induced by type I interferon signaling cause lysis ofFrancisella bacteria that have reached the host-cell cytosol. The liberated bacterial DNA is then sensed by the cytosolic AIM2 inflammasome, which activates caspase-1 and leads to pyroptotic cell death.
DOI of Published Version
Nat Immunol. 2015 May;16(5):443-4. doi: 10.1038/ni.3144. Link to article on publisher's site
Fitzgerald KA, Rathinam VA. (2015). GBPs take AIM at Francisella. UMass Chan Medical School Faculty Publications. https://doi.org/10.1038/ni.3144. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1001