University of Massachusetts Medical School Faculty Publications

 

This collection showcases journal articles, book chapters, and other publications and presentations written by faculty and researchers at the University of Massachusetts Medical School.

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Publications from 2019

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A chromosome folding intermediate at the condensin-to-cohesin transition during telophase, Kristin Abramo, Anne-Laure Valton, Sergey V. Venev, Hakan Ozadam, A. Nicole Fox, and Job Dekker

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Progressive alignment with Cactus: a multiple-genome aligner for the thousand-genome era, Joel Armstrong, Elinor K. Karlsson, and Benedict Paten

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Tumor cell-organized fibronectin is required to maintain a dormant breast cancer population, Lauren E. Barney, Christopher L. Hall, Alyssa D. Schwartz, Akia N. Parks, Christopher Sparages, Sualyneth Galarza, Manu O. Platt, Arthur M. Mercurio, and Shelly R. Peyton

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Distinct features of nucleolus-associated domains in mouse embryonic stem cells, Aizhan Bizhanova, Aimin Yan, Jun Yu, Lihua Julie Zhu, and Paul D. Kaufman

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Constrained mutational sampling of amino acids in HIV-1 protease evolution, Jeffrey I. Boucher, Troy W. Whitfield, Ann Dauphin, Gily S. Nachum, Carl Hollins III, Konstantin B. Zeldovich, Ronald Swanstrom, Celia A. Schiffer, Jeremy Luban, and Daniel N. Bolon

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Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in Reconstructed Human Epidermis, Laura Cau, Hidenari Takahara, Paul R. Thompson, Guy Serre, Marie-Claire Mechin, and Michel Simon

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Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer, A. J. Fritz, Jeffrey A. Nickerson, Anthony N. Imbalzano, and Gary S. Stein

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RUNX1-dependent mechanisms in biological control and dysregulation in cancer, Deli Hong, Andrew J. Fritz, Jonathan A. Gordon, Coralee E. Tye, Joseph R. Boyd, Kirsten M. Tracy, Seth E. Frietze, Frances E. Carr, Jeffrey A. Nickerson, Andre J. Van Wijnen, Anthony N. Imbalzano, Sayyed K. Zaidi, Jane B. Lian, Janet L. Stein, and Gary S. Stein

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Pathognomonic and epistatic genetic alterations in B-cell non-Hodgkin lymphoma, Man Chun John Ma, Benjamin J. Chen, and Michael R. Green

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Mutations in the SPTLC1 gene are a cause of amyotrophic lateral sclerosis that may be amenable to serine supplementation, Janel O. Johnson, Ruth Chia, Robert H. Brown Jr., and John E. Landers

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Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis, Shashi Kant, Siobhan M. Craige, Kai Chen, Michaella M. Reif, Heather Learnard, Mark Kelly, Amada D. Caliz, Khanh-Van T. Tran, Kasmir Ramo, Owen M. Peters, Marc R. Freeman, Roger J. Davis, and John F. Keaney Jr.

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Ste5 Membrane Localization Allows MAPK Pathway Signaling in trans Between Kinases on Separate Scaffold Molecules, Rachel E. Lamson, Matthew J. Winters, and Peter M. Pryciak

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Chitosan biosynthesis and virulence in the human fungal pathogen Cryptococcus gattii, Woei C. Lam, Rajendra Upadhya, Charles A. Specht, Abigail E. Ragsdale, Camaron R. Hole, Stuart M. Levitz, and Jennifer K. Lodge

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The aminoalkylindole, BML-190, negatively regulates chitosan synthesis via the cAMP/PKA1 pathway in Cryptococcus neoformans, Brian T. Maybruck, Woei C. Lam, Charles A. Specht, Ma Xenia G. Ilagan, Maureen J. Donlin, and Jennifer K. Lodge

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Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination, Santanu Mondal and Paul R. Thompson

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BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancer, Rohini Muthuswami, LeeAnn Bailey, Radhakrishnan Rakesh, Anthony N. Imbalzano, Jeffrey A. Nickerson, and Joel W. Hockensmith

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A Novel PHOX/CD38/MCOLN1/TFEB Axis Important For Macrophage Activation During Bacterial Phagocytosis, Mehran Najibi, Joseph A. Moreau, Havisha H. Honwad, and Javier E. Irazoqui

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Co-option of the gibbon-specific LAVA retrotransposon in DNA repair pathways, Mariam Okhovat, Kimberly A. Nevonen, Brett Davis, Pryce S. Michener, Samantha Ward, Mark Milhaven, Lana Harshman, Ajuni Sohota, Rachel J. O’Neill, Nadav Ahituv, Krishna R. Veeramah, and Lucia Carbone

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Leptin promotes expression of EMT-related transcription factors and invasion in a Src and FAK-dependent pathway in MCF10A mammary epithelial cells, Monserrat Olea-Flores, Miriam Zuñiga-Eulogio, Arvey Tacuba-Saavedra, Magdalena Bueno-Salgado, Andrea Sánchez-Carvajal, Yovani Vargas-Santiago, Miguel A. Mendoza-Catalán, Eduardo Pérez Salazar, Alejandra García-Hernández, Teresita Padilla-Benavides, and Napoleón Navarro-Tito

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Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors, Aysegul Ozen, Kristina L. Prachanronarong, Ashley N. Matthew, Djade I. Soumana, and Celia A. Schiffer

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Adaptive evolution targets a piRNA precursor transcription network, Swapnil S. Parhad, Tianxiong Yu, Gen Zhang, Nicholas P. Rice, Zhiping Weng, and William E. Theurkauf

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Signaling to TRP53 and TAp63 from CHK1/CHK2 is responsible for elimination of most oocytes defective for either chromosome synapsis or recombination, Vera D. Rinaldi, Jordana C. Bloom, and John C. Schimenti

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FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism, Sneha Shah, Gemma Molinaro, Botao Liu, Ruijia Wang, Kimberly M. Huber, and Joel D. Richter

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Genetic Rescue of Fragile X Syndrome Links FMRP Deficiency to Codon Optimality-Dependent RNA Destabilization, Huan Shu, Elisa Donnard, Botao Liu, and Joel D. Richter

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Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury, Nicoletta Sorvillo, Daniella M. Mizurini, Carmen Coxon, Kimberly Martinod, Ronak Tilvawala, Deya Cherpokova, Ari J. Salinger, Robert J. Seward, Caleb Staudinger, Eranthie Weerapana, Nathan I. Shapiro, Catherine E. Costello, Paul R. Thompson, and Denisa D. Wagner

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TALE and NF-Y co-occupancy marks enhancers of developmental control genes during zygotic genome activation in zebrafish, William J. Stanney III, Franck Ladam, Ian J. Donaldson, Teagan J. Parsons, Rene Maehr, Nicoletta Bobola, and Charles G. Sagerstrom

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Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure, Nicholas P. Stone, Gabriel Demo, Emily Agnello, and Brian A. Kelch

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Oral administration of an anti-CfaE secretory IgA antibody protects against Enterotoxigenic Escherichia coli diarrheal disease in a non-human primate model, Matteo Stoppato, Carlos Gaspar, James Regeimbal, Gladys Nunez, Serena Giuntini, Melissa A. Gawron, Jessica R. Pondish, Joseph C. Martin III, Matthew Schneider, Zachary A. Schiller, Mark S. Klempner, Lisa A. Cavacini, and Yang Wang

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Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function, Carolyn G. Sweeney, Patrick Kearney, Rita R. Fagan, Lindsey A. Smith, Nicholas C. Bolden, Rubing Zhao-Shea, Iris V. Rivera, Jenya Kolpakova, Jun Xie, Guangping Gao, Andrew R. Tapper, Gilles E. Martin, and Haley Melikian

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MTF1, a classic metal sensing transcription factor, promotes myogenesis in response to copper, Cristina Tavera-Montañez, Sarah J. Hainer, Daniella Cangussu, Shellaina J. V. Gordon, Yao Xiao, Pablo Reyes-Gutierrez, Anthony N. Imbalzano, Juan G. Navea, Thomas G. Fazzio, and Teresita Padilla-Benavides

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Peptidyl arginine deiminases: detection and functional analysis of protein citrullination, Ronak Tilvawala and Paul R. Thompson

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Molecular and structural mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir, Jennifer Timm, Klajdi Kosovrasti, Mina Henes, Florian Leidner, Shurong Hou, Akbar Ali, Nese Kurt Yilmaz, and Celia A. Schiffer

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Evaluation of IL-1 blockade as a host-directed therapy for tuberculosis in mice and macaques, Caylin G. Winchell, Bibhuti B. Mishra, University of Massachusetts Medical School, Samantha J. Nelson, Christopher M. Sassetti, and JoAnne L. Flynn

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Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury, Sanda Win, Robert W. M. Min, Christopher Q. Chen, Jun Zhang, Yibu Chen, Meng Li, Ayako Suzuki, Manal F. Abdelmalek, Ying Wang, Mariam Aghajan, Filbert W. M. Aung, Anna Mae Diehl, Roger J. Davis, Tin A. Than, and Neil Kaplowitz

Publications from 2018

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Post-Acute Care Setting, Facility Characteristics, and Post-Stroke Outcomes: A Systematic Review, Matthew Alcusky, Christine M. Ulbricht, and Kate L. Lapane

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Discordance of voluntary HIV testing with HIV sexual risk-taking and self-perceived HIV infection risk among social media-using black, Hispanic, and white young-men-who-have-sex-with-men (YMSM), Kelsey A. Alexovitz, Roland C. Merchant, Melissa A. Clark, Tao Liu, Joshua G. Rosenberger, Jose Bauermeister, and Kenneth H. Mayer

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NmeCas9 is an intrinsically high-fidelity genome editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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Alcohol and Drug Use among Deaf and Hard-of-Hearing Individuals: A Secondary Analysis of NHANES 2013-2014, Melissa L. Anderson, Bei-Hung Chang, and Nisha Kini

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Do Skeletal Dynamics Mediate Sugar Uptake and Transport in Human Erythrocytes, Robert J. Asaro, Qiang Zhu, Pedro Cabrales, and Anthony Carruthers

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Acute-on-Chronic Liver Failure: Getting ready for prime-time, Jasmohan S. Bajaj, Richard Moreau, Patrick S. Kamath, Hugo E. Vargas, Vicente Arroyo, K. Rajender Reddy, Gyongyi Szabo, Puneeta Tandon, Jody Olson, Constantine Karvellas, Thierry Gustot, Jennifer C. Lai, and Florence Wong

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The TRIM-NHL protein NHL-2 is a Novel Co-Factor of the CSR-1 and HRDE-1 22G-RNA Pathways, Peter R. Boag, Gregory M. Davis, Shikui Tu, Rhys N. Colson, Joshua W. T. Anderson, Menachem J. Gunzburg, Michelle A. Francisco, Debashish Ray, Tuhin Maity, Monica Z. Wu, Quaid D. Morris, Timothy R. Hughes, Jacqueline A. Wilce, University of Toronto, and Zhiping Weng

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Safe and effective superoxide dismutase 1 silencing using artificial microRNA in macaques, Florie Borel, Gwladys Gernoux, Huaming Sun, Rachel Stock, Meghan Blackwood, Robert H. Brown Jr., and Christian Mueller

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Cell clustering mediated by the adhesion protein PVRL4 is necessary for alpha6beta4 integrin-promoted ferroptosis resistance in matrix-detached cells, Caitlin W. Brown, John J. Amante, and Arthur M. Mercurio

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A Persistence Detector for Metabolic Network Rewiring in an Animal, Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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Recovery Services and Outcomes in a State Psychiatric Hospital, Bei-Hung Chang, Jeffrey L. Geller, and Kathleen Biebel

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Effects of Larval Density on Gene Regulation in Caenorhabditis elegans During Routine L1 Synchronization, Io Long Chan, Oliver J. Rando, and Colin C. Conine

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Assuring Integrity in the Residency Match Process, Sonia N. Chimienti, Deborah M. DeMarco, Terence R. Flotte, and Michael F. Collins

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Tumor Necrosis Factor-producing T-regulatory Cells Are Associated With Severe Liver Injury in Patients With Acute Hepatitis A, Yoon Seok Choi, Jun R. Huh, and Eui-Cheol Shin

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Small RNAs gained during epididymal transit of sperm are essential for embryonic development in mice, Colin C. Conine, Fengyun Sun, Lina Song, Jaime A. Rivera-Perez, and Oliver J. Rando

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How well does early-career investigators' cardiovascular outcomes research training align with funded outcomes research, Matthew J. Crowley, Sana M. Al-Khatib, Tracy Y. Wang, Prateeti Khazanie, Nancy R. Kressin, Harlan M. Krumholz, Catarina I. Kiefe, Barbara L. Wells, Sean M. O'Brien, Eric D. Peterson, and Gillian D. Sanders

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Development and evaluation of a capacity building program in gender-relevant tobacco control research: A Brazilian experience, Regina C. Cruz, Sharina D. Person, Lorna Bittencourt, Ana C. Efing, and Isabel C. Scarinci

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Nuclear Export Through Nuclear Envelope Remodeling in Saccharomyces cerevisiae, Baojin Ding, Anne M. Mirza, James A. Ashley, Vivian Budnik, and Mary Munson

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Cognitive Impairment and Pain Among Nursing Home Residents With Cancer, Catherine E. Dube, Deborah Mack, Jacob N. Hunnicutt, and Kate L. Lapane

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VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP beta2-chimaerin, Ameer L. Elaimy, Santosh Guru, Cheng Chang, Jianhong Ou, John J. Amante, Lihua Julie Zhu, Hira Lal Goel, and Arthur M. Mercurio

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Heterochromatin drives organization of conventional and inverted nuclei, Martin Falk; Yana Feodorova; Natasha Naumova; Massachusetts Institute of Technology; Illumina Incorporated; Heinrich Leonhardt; Ludwig Maximilians Universitat, Munchen; Job Dekker; University of California, San Francisco; Ludwig Maximilians Universitat, Munchen; and Massachusetts Institute of Technology

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Elimination of PCR duplicates in RNA-seq and small RNA-seq using unique molecular identifiers, Yu Fu, Pei-Hsuan Wu, Timothy J. Beane, Phillip D. Zamore, and Zhiping Weng

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C-BERST: Defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2, Xin D. Gao, Li-Chun Tu, Aamir Mir, Tomas Rodriguez, Yue-He Ding, John D. Leszyk, Job Dekker, Scott A. Shaffer, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays, Yingying Geng, Hira Lal Goel, Ngoc B. Le, Tatsuyuki Yoshii, Rubul Mout, Gulen Y. Tonga, John J. Amante, Arthur M. Mercurio, and Vincent M. Rotello

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Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance, Devram S. Ghorpade, Lale Ozcan, Ze Zheng, Sarah M. Nicoloro, Yuefei Shen, Emily Chen, Matthias Bluher, Michael P. Czech, and Ira Tabas

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The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution, Nomeda A. Girnius, Yvonne J. K. Edwards, and Roger J. Davis

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The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation, Nomeda A. Girnius, Yvonne J. K. Edwards, David S. Garlick, and Roger J. Davis

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First, Do No Harm: Referring Primary Care Patients with Depression to an Internet Support Group, Brady C. Goodwin, Daniel E. Ford, Robert C. Hsiung, Thomas K. Houston, Joshua Fogel, and Benjamin W. Van Voorhees

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Manganese influx and expression of ZIP8 is essential in primary myoblasts and contributes to activation of SOD2, Shellaina J. V. Gordon, Daniel E. Fenker, Katherine E. Vest, and Teresita Padilla-Benavides

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Unexpected cell population gives fat a brake, David A. Guertin

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Neuronal Modulation of Brown Adipose Activity Through Perturbation of White Adipocyte Lipogenesis, Adilson L. Guilherme, David J. Pedersen, Felipe Henriques, Alexander H. Bedard, Elizabeth Henchey, Mark Kelly, Kamal Rahmouni, Donald A. Morgan, and Michael P. Czech

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Profiling of pluripotency factors in individual stem cells and early embryos, Sarah J. Hainer, Ana Boskovic, Oliver J. Rando, and Thomas G. Fazzio

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Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans, Suraiya Haroon, Annie Li, Jaye L. Weinert, Clark Fritsch, Nolan G. Ericson, Jasmine Alexander-Floyd, Bart P. Braeckman, Cole M. Haynes, Jason H. Bielas, Tali Gidalevitz, and Marc Vermulst

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Feasibility and Acceptability of Mindfulness for Survivors of Homicide and Their Providers, Stephanie W. Hartwell, Jeroan J. Allison, Bonita Jones, Rachel Rodrigues, Clementina Chery, Julianna Andrews, and Carl E. Fulwiler

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Problems in Meta-Analysis of Comparative Effectiveness of Conservative Interventions for Nonspecific Chronic Spinal Pain, David C. Hoaglin

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UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response, L. N. Huiting, Y. Samaha, G. L. Zhang, Justine E. Roderick, B. Li, N. M. Anderson, Y. W. Wang, L. Wang, F. Laroche, J. W. Choi, C. T. Liu, Michelle A. Kelliher, and H. Feng

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All-in-One Adeno-associated Virus Delivery and Genome Editing by Neisseria meningitidis Cas9 in vivo, Raed Ibraheim, Chun-Qing Song, Aamir Mir, Nadia Amrani, Wen Xue, and Erik J. Sontheimer

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A synthetic, three-dimensional bone marrow hydrogel, Lauren Jansen, Thomas McCarthy, Michael J. Lee, and Shelly Peyton

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Dynamics of human protein kinases linked to drug selectivity, Dorothee Kern, Warintra Pitsawong, Brandeis University, Renee Otten, Roman V. Agafonov, Adelajda Zorba, Nadja Kern, Steffen Kutter, Gunther Kern, Ricardo A.P. Pádua, and Xavier Meniche

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Training cardiovascular outcomes researchers: A survey of mentees and mentors to identify critical training gaps and needs, Prateeti Khazanie, Sana M. Al-Khatib, Tracy Y. Wang, Matthew J. Crowley, Nancy R. Kressin, Harlan M. Krumholz, Catarina I. Kiefe, Barbara L. Wells, Sean M. O'Brien, Eric D. Peterson, and Gillian D. Sanders

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Geographic Diffusion and Implementation of Acute Care Surgery: An Uneven Solution to the National Emergency General Surgery Crisis, Jasmine A. Khubchandani, Angela M. Ingraham, Vijaya Daniel, M. Didem Ayturk, Catarina I. Kiefe, and Heena Santry

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Disparities in access to emergency general surgery care in the United States, Jasmine A. Khubchandani, Connie Shen, M. Didem Ayturk, Catarina I. Kiefe, and Heena P. Santry

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Caste matters: perceived discrimination among women in rural India, Jasmine A. Khubchandani, Apurv Soni, Nisha Fahey, Nitin Raithatha, Anusha Prabhakaran, Nancy Byatt, Tiffany A. Moore Simas, Ajay Phatak, Milagros C. Rosal, Somashekhar Nimbalkar, and Jeroan J. Allison

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CDKN2A/B T2D GWAS Risk-SNPs Impact Locus Gene Expression and Proliferation in Human Islets, Yahui Kong, Rohit B. Sharma, Socheata Ly, Rachel E. Stamateris, William M. Jesdale, and Laura C. Alonso

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A unified encyclopedia of human functional DNA elements through fully automated annotation of 164 human cell types, Maxwell Wing Libbrecht, Oscar Rodriguez, Zhiping Weng, Michael Hoffman, Jeffrey A. Bilmes, and William Stafford Noble

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Syndromic congenital myelofibrosis associated with a loss-of-function variant in RBSN, Pilar L. Magoulas, Silvia Corvera, and Luis M. Franco

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Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation, Purvi Mande, Bahar Zirak, Wei-Che Ko, Keyon Taravati, Karen L. Bride, Tia Bumpus Brodeur, April C. Deng, Karen A. Dresser, Zhaozhao Jiang, Rachel Ettinger, Katherine A. Fitzgerald, Michael D. Rosenblum, John E. Harris, and Ann Marshak-Rothstein

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UPR(mt) regulation and output: a stress response mediated by mitochondrial-nuclear communication, Andrew Melber and Cole M. Haynes

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Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2, Jose Mercado-Matos, Jenny Janusis, Sha Zhu, Samuel S. Chen, and Leslie M. Shaw

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Higher-Order Organization Principles of Pre-translational mRNPs, Mihir Metkar, Hakan Ozadam, Bryan R. Lajoie, Maxim Imakaev, Leonid A. Mirny, Job Dekker, and Melissa J. Moore

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Heavily and Fully Modified RNAs Guide Efficient SpyCas9-Mediated Genome Editing, Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, and Erik J. Sontheimer

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JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory, Caroline Morel, Tessi Sherrin, Norman J. Kennedy, Kelly H. Forest, Seda Barutcu, Michael Robles, Ezekiel Carpenter-Hyland, Naghum Alfulaij, Claire L. Standen, Robert A. Nichols, Morris Benveniste, Roger J. Davis, and Cedomir Todorovic

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ORBIT: a new paradigm for genetic engineering of mycobacterial chromosomes, Kenan C. Murphy, Samantha J. Nelson, Subhalaxmi Nambi, Kadamba Papavinasasundaram, Christina E. Baer, and Christopher M. Sassetti

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C. elegans Multidrug Resistance Protein 5 (MRP-5) Transports Vitamin B12 from the Intestine to the Gonad to Support Embryonic Development, Huimin Na, Olga Ponomarova, Gabrielle E. Giese, and Albertha J. M. Walhout

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A new in vitro assay measuring direct interaction of nonsense suppressors with the eukaryotic protein synthesis machinery, Martin Y. Ng, Haibo Zhang, Amy Weil, Vijay Singh, Ryan M. Jamiolkowski, Alireza Baradaran-Heravi, Michel Roberge, Allan Jacobson, Ellen Welch, Yale Goldman, and Barry S. Cooperman

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ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data, Jianhong Ou, Haibo Liu, Jun Yu, Michelle A. Kelliher, Lucio H. Castilla, Nathan D. Lawson, and Lihua Julie Zhu

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Resistance from Afar: Distal Mutation V36M Allosterically Modulates the Active Site to Accentuate Drug Resistance in HCV NS3/4A Protease, Aysegul Ozen, Kuan-Hung Lin, Keith P. Romano, Davide Tavella, Alicia Newton, Christos J. Petropoulos, Wei Huang, Cihan Aydin, and Celia A. Schiffer

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Numerous recursive sites contribute to accuracy of splicing of long introns in flies, Athma A. Pai, Joseph Paggi, Karen Adelman, and Christopher B. Burge

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Gain of Function Analysis Reveals Non-Redundant Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA, Samantha G. Palace, Megan K. Proulx, Rose L. Szabady, and Jon D. Goguen

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Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa, Lolita Petit, Shan Ma, Joris Cipi, Shun-Yun Cheng, Marina Zieger, Nissim Hay, and Claudio Punzo

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Mitochondrial Biogenesis: MitoCPR Resuscitates Import-Defective Mitochondria, Jacqueline Pires and Cole M. Haynes

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A novel sialylation site on Neisseria gonorrhoeae lipooligosaccharide links heptose II lactose expression with pathogenicity, Sanjay Ram, Sunita Gulati, Lisa A. Lewis, Srinjoy Chakraborti, Bo Zheng, Rosane B. de Oliveira, George W. Reed, Andrew D. Cox, Jianjun Li, Frank St. Michael, Jacek Stupak, Xiao-Hong Su, Sudeshna Saha, Corinna S. Landig, Ajit Varki, and Peter A. Rice

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Effects of larval density on gene regulation in C. elegans during routine L1 synchronization, Oliver J. Rando, Io Long Chan, and Colin C. Conine

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OMEGA: a software tool for the management, analysis, and dissemination of intracellular trafficking data that incorporates motion type classification and quality control, Alessandro Rigano, Vanni Galli, Jasmine M. Clark, Lara E. Pereira, Loris Grossi, Jeremy Luban, Raffaello Giulietti, Tiziano Leidi, Eric Hunter, Mario Valle, Ivo F. Sbalzarini, and Caterina Strambio-De-Castilla

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Charcot-Leyden Crystals activate the NLRP3 inflammasome and cause IL-1β inflammation, Juan Francisco Rodrigues-Alcazar, Marco A. Ataide, Gudrun Engels, Christine Schmitt-Mabmunyo, Natalio Garbi, Wolfgang Kastenmueller, Eicke Latz, and Bernardo S. Franklin

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IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer, Sanjoy Samanta, Santosh Guru, Ameer L. Elaimy, John J. Amante, Jianhong Ou, Jun Yu, Lihua Julie Zhu, and Arthur M. Mercurio