Dystrophic epidermolysis bullosa associated with amniotic band syndrome

UMMS Affiliation

Division of Dermatology; Department of Medicine; School of Medicine



Document Type



Dermatology | Skin and Connective Tissue Diseases


Amniotic band syndrome (ABS) is a term used to describe congenital anomalies that result from the entrapment of a fetus in fibrous bands. We describe two male infants born with features of dystrophic epidermolysis bullosa (DEB) and ABS. These cases add to the few previous reports of simultaneous DEB and ABS. Abnormal type VII collagen in anchoring structures of the amniotic epithelium is a proposed mechanism for loose amniotic bands that entangle the fetus, with an abnormality in the gene that encodes for type VII collagen.

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Citation: Pediatr Dermatol. 2014 Mar-Apr;31(2):212-6. doi: 10.1111/pde.12285. Epub 2014 Jan 3. Link to article on publisher's site

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