Title
Immunology and skin in health and disease
UMMS Affiliation
Division of Dermatology
Publication Date
2014-12-01
Document Type
Article
Disciplines
Dermatology | Skin and Connective Tissue Diseases
Abstract
The skin is a complex organ that, in addition to providing a strong barrier against external insults, serves as an arena for a wide variety of inflammatory processes, including immunity against infections, tumor immunity, autoimmunity, and allergy. A variety of cells collaborate to mount functional immune responses, which are initiated by resident populations and evolve through the recruitment of additional cell populations to the skin. Inflammatory responses are quite diverse, resulting in a wide range of signs and symptoms that depend on the initiating signals, characteristics of the infiltrating cell populations, and cytokines that are produced (cytokines are secreted protein that allows for cell-cell communication; usually refers to communication between immune-immune cells or stromal-immune cells). In this work, we will review the skin architecture and resident and recruited cell populations and discuss how these populations contribute to inflammation using human diseases and treatments when possible to illustrate their importance within a clinical context.
DOI of Published Version
10.1101/cshperspect.a015339
Source
Cold Spring Harb Perspect Med. 2014 Dec 1;4(12):a015339. doi: 10.1101/cshperspect.a015339. Link to article on publisher's site
Journal/Book/Conference Title
Cold Spring Harbor perspectives in medicine
Related Resources
PubMed ID
25452424
Repository Citation
Richmond, Jillian M. and Harris, John E., "Immunology and skin in health and disease" (2014). Dermatology Publications and Presentations. 84.
https://escholarship.umassmed.edu/derm_pubs/84