Title
Histologic pattern analysis of basal cell carcinoma. Study of a series of 1039 consecutive neoplasms
UMMS Affiliation
Department of Medicine, Division of Dermatology
Publication Date
1990-12-01
Document Type
Article
Subjects
Carcinoma, Basal Cell; Humans; Skin Neoplasms
Disciplines
Dermatology | Neoplasms | Skin and Connective Tissue Diseases
Abstract
This study attempts to define histologic patterns in 1039 consecutive cases of basal cell carcinoma and to correlate these patterns with adequacy of margins of surgical excision. Five major histologic patterns were identified: nodular, 218 cases (21%); superficial, 181 cases (17%); micronodular, 151 cases (15%); infiltrative, 77 cases (7%); and morpheic, 11 cases (1%). A mixed pattern (two or more major histologic patterns) was present in 401 cases (38.5%). Our study indicates that nodular and superficial basal cell carcinomas can be completely removed by simple surgical excision in a high percentage of cases (93.6% and 96.4%, respectively) whereas the micronodular, infiltrative, and morpheic basal cell carcinomas have a higher incidence of positive tumor margins (18.6%, 26.5%, and 33.3%, respectively) after excision. Mixed patterns that consisted of combinations of the nodular, micronodular, or infiltrative types exhibited a behavior similar to the pattern that resulted in a greater chance of incomplete surgical removal.
DOI of Published Version
10.1016/0190-9622(90)70344-H
Source
J Am Acad Dermatol. 1990 Dec;23(6 Pt 1):1118-26. doi:10.1016/0190-9622(90)70344-H
Journal/Book/Conference Title
Journal of the American Academy of Dermatology
Related Resources
PubMed ID
2273112
Repository Citation
Sexton FM, Jones DB, Maloney ME. (1990). Histologic pattern analysis of basal cell carcinoma. Study of a series of 1039 consecutive neoplasms. Dermatology Publications. https://doi.org/10.1016/0190-9622(90)70344-H. Retrieved from https://escholarship.umassmed.edu/derm_pubs/5
Comments
At the time of publication, Mary E. Maloney was not yet affiliated with the University of Massachusetts Medical School.