Prospective evaluation of dermatologic surgery complications including patients on multiple antiplatelet and anticoagulant medications
Department of Medicine, Division of Dermatology
Aged; Ambulatory Surgical Procedures; Antibiotic Prophylaxis; Anticoagulants; *Dermatologic Surgical Procedures; Female; Humans; Male; Mohs Surgery; Necrosis; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Hemorrhage; Surgical Flaps; Surgical Wound Infection; Ticlopidine; Warfarin
Dermatology | Skin and Connective Tissue Diseases
BACKGROUND: Few prospective studies have evaluated the safety of dermatologic surgery.
OBJECTIVE: We sought to determine rates of bleeding, infection, flap and graft necrosis, and dehiscence in outpatient dermatologic surgery, and to examine their relationship to type of repair, anatomic location of repair, antibiotic use, antiplatelet use, or anticoagulant use.
METHODS: Patients presenting to University of Massachusetts Medical School Dermatology Clinic for surgery during a 15-month period were prospectively entered. Medications, procedures, and complications were recorded.
RESULTS: Of the 1911 patients, 38% were on one anticoagulant or antiplatelet medication, and 8.0% were on two or more. Risk of hemorrhage was 0.89%. Complex repair (odds ratio [OR] = 5.80), graft repair (OR = 7.58), flap repair (OR = 11.93), and partial repair (OR = 43.13) were more likely to result in bleeding than intermediate repair. Patients on both clopidogrel and warfarin were 40 times more likely to have bleeding complications than all others (P = .03). Risk of infection was 1.3%, but was greater than 3% on the genitalia, scalp, back, and leg. Partial flap necrosis occurred in 1.7% of flaps, and partial graft necrosis occurred in 8.6% of grafts. Partial graft necrosis occurred in 20% of grafts on the scalp and 10% of grafts on the nose. All complications resolved without sequelae.
LIMITATIONS: The study was limited to one academic dermatology practice.
CONCLUSION: The rate of complications in dermatologic surgery is low, even when multiple oral anticoagulant and antiplatelet medications are continued, and prophylactic antibiotics are not used. Closure type and use of warfarin or clopidogrel increase bleeding risk. However, these medications should be continued to avoid adverse thrombotic events. All rights reserved.
DOI of Published Version
Bordeaux JS, Martires KJ, Goldberg D, Pattee SF, Fu P, Maloney ME. Prospective evaluation of dermatologic surgery complications including patients on multiple antiplatelet and anticoagulant medications. J Am Acad Dermatol. 2011 Sep;65(3):576-83. doi: 10.1016/j.jaad.2011.02.012.
Journal of the American Academy of Dermatology
Bordeaux JS, Martires KJ, Goldberg D, Pattee SF, Fu P, Maloney ME. (2011). Prospective evaluation of dermatologic surgery complications including patients on multiple antiplatelet and anticoagulant medications. Dermatology Publications. https://doi.org/10.1016/j.jaad.2011.02.012. Retrieved from https://escholarship.umassmed.edu/derm_pubs/33