eScholarship@UMMS

Title

Cell surface molecules in basal cell carcinomas

Authors

Mary Pentel, Pennsylvania State University
Klaus F. Helm, Pennsylvania State University
Mary E. Maloney, University of Massachusetts Medical SchoolFollow

UMMS Affiliation

Department of Medicine, Division of Dermatology

Publication Date

1995-10-01

Document Type

Article

Subjects

Adult; Aged; Carcinoma, Basal Cell; Cell Adhesion Molecules; Female; Humans; Immunoglobulins; Integrins; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Selectins; Skin Neoplasms

Disciplines

Dermatology | Neoplasms | Skin and Connective Tissue Diseases

Abstract

BACKGROUND: The factors determining a basal cell carcinoma's (BCC's) growth pattern and invasive potential are not known. In other tumors it has been shown recently that the expression of cellular adhesion molecules may determine a tumor's invasive and metastatic potential. Integrins, cell surface molecules important in cell stroma interactions, are present on BCCs and may help regulate the tumor's growth pattern.

OBJECTIVE: We compared the expression of cellular adhesion molecules alpha 2 integrin, beta 1 integrin, intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), leukocyte function antigen 1a (LFA-1a), and E-selectin in different histological subtypes of basal cell carcinomas.

METHODS: BCCs were obtained from patients undergoing Mohs surgery. The BCCs were classified as nodular, micronodular, mixed, infiltrative, and basosquamous types and stained using an avidin-biotin-immunoperoxidase technique with antibodies against alpha 2 integrin, beta 1 integrin, ICAM, LFA-1a, VCAM-1, and E-selectin.

RESULTS: BCCs expressed alpha 2 and beta 1 integrin, but no significant differences in the amount or pattern of expression was seen in the different histologic subtypes.

CONCLUSION: The expression of integrins by BCCs by binding to the surrounding stroma may limit BCC's growth; however, their expression does not appear to correlate with their histological pattern.

DOI of Published Version

10.1111/j.1524-4725.1995.tb00712.x

Source

Dermatol Surg. 1995 Oct;21(10):858-61. doi:10.1111/j.1524-4725.1995.tb00712.x

Journal/Book/Conference Title

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Comments

At the time of publication, Mary E. Maloney was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

7551741

Repository Citation

Pentel, Mary; Helm, Klaus F.; and Maloney, Mary E., "Cell surface molecules in basal cell carcinomas" (1995). Dermatology Publications and Presentations. 16.
https://escholarship.umassmed.edu/derm_pubs/16