This collection showcases the journal articles and other publications authored by researchers in the Roger Davis Lab in the Program in Molecular Medicine at the University of Massachusetts Medical School. The cJun NH2-terminal kinase (JNK) signal transduction pathway is implicated in several stress-related disease processes including cancer, diabetes, inflammation, and stroke. Our hope is that drugs targeting the JNK pathway may be useful for the treatment of these diseases. The goal of this laboratory is to understand the molecular processes that are engaged by JNK in both health and disease.

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Publications from 2010

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Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration, Monia Barnat, Herve Enslen, Friedrich Propst, Roger J. Davis, Sylvia Soares, and Fatiha Nothias

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Role of JNK in a Trp53-dependent mouse model of breast cancer, Cristina Arrigo Cellurale, Claire R. Weston, Judith Reilly, David S. Garlick, D. Joseph Jerry, Hayla Karen Sluss, and Roger J. Davis

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The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice, Matthew B. Greenblatt, Jae-Hyuck Shim, Weiguo Zou, Despina Sitara, Michelle Schweitzer, Dorothy Hu, Sutada Lotinun, Yasuyo Sano, Roland Baron, Jin Mo Park, Simon Arthur, Min Xie, Michael D. Schneider, Bo Zhai, Steven Gygi, Roger J. Davis, and Laurie H. Glimcher

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JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint, Gustavo J. Gutierrez, Toshiya Tsuji, Janet V. Cross, Roger J. Davis, Dennis J. Templeton, Wei Jiang, and Ze'ev A. Ronai

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Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo, Anette Hubner, Julie Cavanagh-Kyros, Mercedes Rincon, Richard Flavell, and Roger J. Davis

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Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance, Caroline Morel, Claire L. Standen, Dae Young Jung, Susan Gray, Helena Ong, Richard A. Flavell, Jason K. Kim, and Roger J. Davis

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Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation, Monika Podkowa, Xin Zhao, Chi-Wing Chow, Eleanor T. Coffey, Roger J. Davis, and Liliana Attisano

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Differential activation of p38MAPK isoforms by MKK6 and MKK3, Gaelle Remy, Ana M. Risco, Francisco A. Inesta-Vaquera, Barbara Gonzalez-Teran, Guadalupe Sabio, Roger J. Davis, and Ana Cuenda

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Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1, Guadalupe Sabio, Julie Cavanagh-Kyros, Tamera Barrett, Dae Young Jung, Hwi Jin Ko, Helena Ong, Caroline Morel, Alfonso Mora, Judith Reilly, Jason K. Kim, and Roger J. Davis

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cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance, Guadalupe Sabio and Roger J. Davis

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Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance, Guadalupe Sabio, Norman J. Kennedy, Julie Cavanagh-Kyros, Dae Young Jung, Hwi Jin Ko, Helena Ong, Tamera Barrett, Jason K. Kim, and Roger J. Davis

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Hippocampal c-Jun-N-terminal kinases serve as negative regulators of associative learning, Tessi Sherrin, Thomas Blank, Cathrin Hippel, Martin Rayner, Roger J. Davis, and Cedomir Todorovic

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AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade, F. Donelson Smith, Lorene K. Langeberg, Cristina Arrigo Cellurale, Tony Pawson, Deborah K. Morrison, Roger J. Davis, and John D. Scott

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c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal, Ping Xu and Roger J. Davis

Publications from 2009

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Induction of hepatitis by JNK-mediated expression of TNF-alpha, Madhumita Das, Guadalupe Sabio, Feng Jiang, Mercedes Rincon, Richard Flavell, and Roger J. Davis

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Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage, Iva V. Klevernic, Simon Morton, Roger J. Davis, and Philip Cohen

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Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice, A. K. H. Lim, David J. Nikolic-Paterson, F. Y. Ma, E. Ozols, M. C. Thomas, Richard Flavell, Roger J. Davis, and Greg H. Tesch

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Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis, Caroline Morel, Scott M. Carlson, Forest M. White, and Roger J. Davis

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Regulation of the immune response by stress-activated protein kinases, Mercedes Rincon and Roger J. Davis

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Prevention of steatosis by hepatic JNK1, Guadalupe Sabio, Julie Cavanagh-Kyros, Hwi Jin Ko, Dae Young Jung, Susan Gray, John Y. Jun, Tamera Barrett, Alfonso Mora, Jason K. Kim, and Roger J. Davis

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Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes, Claire L. Standen, Norman J. Kennedy, Richard A. Flavell, and Roger J. Davis

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Nuclear localization of p38 MAPK in response to DNA damage, C. David Wood, Tina Thornton, Guadalupe Sabio, Roger J. Davis, and Mercedes Rincon

Publications from 2008

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Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1, John F. Alcorn, Amy S. Guala, Jos van der Velden, Brian McElhinney, Charles G. Irvin, Roger J. Davis, and Yvonne M.W. Janssen-Heininger

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Targeting dendritic cell signaling to regulate the response to immunization, David Escors, Luciene Lopes, Rongtuan Lin, John Hiscott, Shizuo Akira, Roger J. Davis, and Mary K. Collins

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Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention, Thomas J. Fitzgerald, Tao Wang, Hira Lal Goel, Jiayi Huang, Gary S. Stein, Jane B. Lian, Roger J. Davis, Stephen J. Doxsey, Kethandapatti C. Balaji, Jesse N. Aronowitz, and Lucia R. Languino

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MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model, Kyoichi Fukuda, Greg H. Tesch, Felicia Y. Yap, Josephine M. Forbes, Richard Flavell, Roger J. Davis, and David J. Nikolic-Paterson

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A genetically encoded fluorescent sensor of ERK activity, Christopher D. Harvey, Anka G. Ehrhardt, Cristina Arrigo Cellurale, Haining Zhong, Ryohei Yasuda, Roger J. Davis, and Karel Svoboda

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Multisite phosphorylation regulates Bim stability and apoptotic activity, Anette Hubner, Tamera Barrett, Richard Flavell, and Roger J. Davis

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c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway, Dong Hu, Wenfeng Fang, Anjia Han, Lindsay Gallagher, Roger J. Davis, Bin Xiong, and Wancai Yang

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Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice, Elizabeth Keramaris, Vladamir A. Ruzhynsky, Steve M. Callaghan, Estelle Wong, Roger J. Davis, Richard Flavell, Ruth S. Slack, and David S. Park

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Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex, Heidi Mendoza, David G. Campbell, Kerry Burness, James Hastie, Natalia Ronkina, Jae-Hyuck Shim, J. Simon C. Arthur, Roger J. Davis, Matthias Gaestel, Gary L. Johnson, Sankar Ghosh, and Philip Cohen

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Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage, Pat P. Ongusaha, Hank H. Qi, Lakshmi Raj, Young-Bum Kim, Stuart A. Aaronson, Roger J. Davis, Yang Shi, James K. Liao, and Sam W. Lee

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c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection, Joao H.F. Pedra, Jochen Mattner, Jian Tao, Steven M. Kerfoot, Roger J. Davis, Richard A. Flavell, Philip W. Askenase, Zhinan Yin, and Erol Fikrig

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A stress signaling pathway in adipose tissue regulates hepatic insulin resistance, Guadalupe Sabio, Madhumita Das, Alfonso Mora, Zhiyou Zhang, John Y. Jun, Hwi Jin Ko, Tamera Barrett, Jason K. Kim, and Roger J. Davis

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Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation, Tina Thornton, Gustavo Pedraza-Alva, Bin Deng, C. David Wood, Alexander Aronshtam, James L. Clements, Guadalupe Sabio, Roger J. Davis, Dwight E. Matthews, Bradley Doble, and Mercedes Rincon

Publications from 2007

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Suppression of p53-dependent senescence by the JNK signal transduction pathway, Madhumita Das, Feng Jiang, Hayla Karen Sluss, Chao Zhang, Kevan M. Shokat, Richard A. Flavell, and Roger J. Davis

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c-Jun N-terminal kinase 1 is required for Toll-like receptor 1 gene expression in macrophages, Hooman Izadi, Amirreza T. Motameni, Tonya C. Bates, Elias R. Olivera, Vega Villar-Suarez, Ila Joshi, Renu Garg, Barbara A. Osborne, Roger J. Davis, Mercedes Rincon, and Juan Anguita

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Metabolic stress signaling mediated by mixed-lineage kinases, Anja Jaeschke and Roger J. Davis

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A radical role for p38 MAPK in tumor initiation, Norman J. Kennedy, Cristina Arrigo Cellurale, and Roger J. Davis

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Requirement of JIP scaffold proteins for NMDA-mediated signal transduction, Norman J. Kennedy, Gilles Martin, Anka G. Ehrhardt, Julie Cavanagh-Kyros, Chia-Yi Kuan, Pasko Rakic, Richard A. Flavell, Steven N. Treistman, and Roger J. Davis

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Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections, Jae Hyang Lim, Roger J. Davis, and Jian-Dong Li

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MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney, Frank Y. Ma, Greg H. Tesch, Richard A. Flavell, Roger J. Davis, and David J. Nikolic-Paterson

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Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes, Ashwini K. Mishra, Laxman Gangwani, Roger J. Davis, and David G. Lambright

Publications from 2006

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Control of cellular senescence by CPEB, Irina Groisman, Maria Ivshina, Veronica Marin, Norman J. Kennedy, Roger J. Davis, and Joel D. Richter

Publications from 2005

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Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades, Deborah Marie Brancho, Juan-Jose Ventura, Anja Jaeschke, Beth Doran, Richard A. Flavell, and Roger J. Davis

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Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes, Anja Jaeschke, Mercedes Rincon, Beth Doran, Judith Reilly, Donna S. Neuberg, Dale L. Greiner, Leonard D. Shultz, Aldo A. Rossini, Richard A. Flavell, and Roger J. Davis

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Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways, Nyaya Kelkar, Claire L. Standen, and Roger J. Davis

Publications from 2004

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An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue, Anja Jaeschke, Michael P. Czech, and Roger J. Davis

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JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species, Juan-Jose Ventura, Patricia C. Cogswell, Richard A. Flavell, Albert S. Baldwin Jr., and Roger J. Davis

Publications from 2003

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Mechanism of p38 MAP kinase activation in vivo, Deborah Marie Brancho, Nobuyuki Tanaka, Anja Jaeschke, Juan-Jose Ventura, Nyaya Kelkar, Yoshinori Tanaka, Masanao Kyuuma, Toshikazu Takeshita, Richard A. Flavell, and Roger J. Davis

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Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3), Nyaya Kelkar, Marie Helene Delmotte, Claire R. Weston, Tamera Barrett, Barbara J. Sheppard, Richard A. Flavell, and Roger J. Davis

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Role of JNK in tumor development, Norman J. Kennedy and Roger J. Davis

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JunD mediates survival signaling by the JNK signal transduction pathway, Jennifer A. Lamb, Juan-Jose Ventura, Patricia M. Hess, Richard A. Flavell, and Roger J. Davis

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JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure, Claire R. Weston, Anthony Wong, J. Perry Hall, Mary E. P. Goad, Richard A. Flavell, and Roger J. Davis

Publications from 2002

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Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis, Nobuyuki Tanaka, Masahito Kamanaka, Herve Enslen, Chen Dong, Mark Allen Wysk, Roger J. Davis, and Richard A. Flavell

Publications from 2001

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Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway, Gerard S. De Zutter and Roger J. Davis

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Molecular basis of T-cell differentiation, Richard A. Flavell, B. Li, Chen Dong, Hong-Tao Lu, Derek D. Yang, Herve Enslen, Cathy Tournier, Alan J. Whitmarsh, Mark Allen Wysk, D. Conze, Mercedes Rincon, and Roger J. Davis

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MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines, Cathy Tournier, Chen Dong, Tod K. Turner, Stephen N. Jones, Richard A. Flavell, and Roger J. Davis

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Requirement of the JIP1 scaffold protein for stress-induced JNK activation, Alan J. Whitmarsh, Chia-Yi Kuan, Norman J. Kennedy, Nyaya Kelkar, Tarik F. Haydar, John P. Mordes, Michael C. Appel, Aldo A. Rossini, Stephen N. Jones, Richard A. Flavell, Pasko Rakic, and Roger J. Davis

Publications from 2000

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Molecular determinants that mediate selective activation of p38 MAP kinase isoforms, Herve Enslen, Deborah Marie Brancho, and Roger J. Davis

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c-Jun N-terminal kinase (JNK) repression during the inflammatory response? Just say NO, J. Perry Hall, Eric Lee Merithew, and Roger J. Davis

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Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3, Nyaya Kelkar, Shashi Gupta, Martin Dickens, and Roger J. Davis

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Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway, Leo E. Otterbein, Fritz H. Bach, Jawed Alam, Miguel P. Soares, Hong-Tao Lu, Mark Allen Wysk, Roger J. Davis, Richard A. Flavell, and Augustine M. K. Choi

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway, Cathy Tournier, Patricia M. Hess, Derek D. Yang, Jie Xu, Tod K. Turner, Anjaruwee S. Nimnual, Dafna Bar-Sagi, Stephen N. Jones, Richard A. Flavell, and Roger J. Davis

Publications from 1999

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Integration of calcium and cyclic AMP signaling pathways by 14-3-3, Chi-Wing Chow and Roger J. Davis

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Requirement for transcription factor NFAT in interleukin-2 expression, Chi-Wing Chow, Mercedes Rincon, and Roger J. Davis

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Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice, Hong-Tao Lu, Derek D. Yang, Mark Allen Wysk, Evelina Gatti, Ira Mellman, Roger J. Davis, and Richard A. Flavell

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WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans, Christian Ernest Rocheleau, Jun Yasuda, Tae Ho Shin, Rueyling Lin, Hitoshi Sawa, Hideyuki Okano, James R. Priess, Roger J. Davis, and Craig C. Mello

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The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases, Cathy Tournier, Alan J. Whitmarsh, Julie Cavanagh, Tamera Barrett, and Roger J. Davis

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The JIP group of mitogen-activated protein kinase scaffold proteins, Jun Yasuda, Alan J. Whitmarsh, Julie Cavanagh, Manoj Sharma, and Roger J. Davis

Publications from 1998

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Defective T cell differentiation in the absence of Jnk1, Chen Dong, Derek D. Yang, Mark Allen Wysk, Alan J. Whitmarsh, Roger J. Davis, and Richard A. Flavell

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Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases, Kimberly K. Elbirt, Alan J. Whitmarsh, Roger J. Davis, and Herbert L. Bonkovsky

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Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6, Herve Enslen, Joel Raingeaud, and Roger J. Davis

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The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells, Zoya Galcheva-Gargova, Laxman Gangwani, Konstantin N. Konstantinov, Monique Mikrut, Steven J. Theroux, Tamar Enoch, and Roger J. Davis

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Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells, Laxman Gangwani, Monique Mikrut, Zoya Galcheva-Gargova, and Roger J. Davis

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A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression, Zhiqiang Han, Herve Enslen, Xiaodi Hu, Xiangjun Meng, I-Huan Wu, Tamera Barrett, Roger J. Davis, and Y. Tony Ip

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Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase, Jean-Marc Jacque, Angela Mann, Herve Enslen, Natalia Sharova, Beda Brichacek, Roger J. Davis, and Mario Stevenson

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A mammalian scaffold complex that selectively mediates MAP kinase activation, Alan J. Whitmarsh, Julie Cavanagh, Cathy Tournier, Jun Yasuda, and Roger J. Davis

Publications from 1997

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Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo, Mark J. Birnbaum, Brigitte van Zundert, Patricia S. Vaughan, Alan J. Whitmarsh, Andre J. Van Wijnen, Roger J. Davis, Gary S. Stein, and Janet L. Stein

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Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway, Chi-Wing Chow, Mercedes Rincon, Julie Cavanagh, Martin Dickens, and Roger J. Davis

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A cytoplasmic inhibitor of the JNK signal transduction pathway, Martin Dickens, Jeffrey Scott Rogers, Julie Cavanagh, Art Raitano, Zhengui Xia, Jocelyn R. Halpern, Michael E. Greenberg, Charles L. Sawyers, and Roger J. Davis

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Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase, Cathy Tournier, Alan J. Whitmarsh, Julie Cavanagh, Tamera Barrett, and Roger J. Davis

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Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors, Alan J. Whitmarsh, Shen-Hsi Yang, Michael S. S. Su, Andrew D. Sharrocks, and Roger J. Davis

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Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity, Di Yang, Cathy Tournier, Mark Allen Wysk, Hong-Tao Lu, Jie Xu, Roger J. Davis, and Richard A. Flavell

Publications from 1996

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Selective interaction of JNK protein kinase isoforms with transcription factors, Shashi Gupta, Tamera Barrett, Alan J. Whitmarsh, Julie Cavanagh, Hayla Karen Sluss, Benoit Derijard, and Roger J. Davis

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MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway, Joel Raingeaud, Alan J. Whitmarsh, Tamera Barrett, Benoit Derijard, and Roger J. Davis

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A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila, Hayla Karen Sluss, Zhiqiang Han, Tamera Barrett, Deborah C. I. Goberdhan, Clive Wilson, Roger J. Davis, and Y. Tony Ip

Publications from 1995

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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine, Joel Raingeaud, Shashi Gupta, Jeffrey Scott Rogers, Martin Dickens, Jiahuai Han, Richard J. Ulevitch, and Roger J. Davis

Publications from 1994

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Signal transduction by tumor necrosis factor mediated by JNK protein kinases, Hayla Karen Sluss, Tamera Barrett, Benoit Derijard, and Roger J. Davis

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The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex, Markus Wartmann and Roger J. Davis

Publications from 1993

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Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62, Shashi Gupta, Alpna Seth, and Roger J. Davis

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cPLA2 is phosphorylated and activated by MAP kinase, Lih-Ling Lin, Markus Wartmann, Alice Y. Lin, John L. Knop, Alpna Seth, and Roger J. Davis

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Mitogen-activated protein kinase stimulation by a tyrosine kinase-negative epidermal growth factor receptor, Erica Marie Selva, David L. Raden, and Roger J. Davis

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Cell cycle regulation of the c-Myc transcriptional activation domain, Alpna Seth, Shashi Gupta, and Roger J. Davis

Publications from 1992

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Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase, Janice L. Countaway, Angus C. Nairn, and Roger J. Davis

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Protein tyrosine kinase activities of the epidermal growth factor receptor and ErbB proteins: correlation of oncogenic activation with altered kinetics, Nandini Nair, Roger J. Davis, and Harriet L. Robinson

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Signal transduction within the nucleus by mitogen-activated protein kinase, Alpna Seth, Fernando A. Gonzalez, Shashi Gupta, David L. Raden, and Roger J. Davis

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Rapid screening of cloned DNA fragments for specific mutations, Steven J. Theroux and Roger J. Davis

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Mutational removal of the major site of serine phosphorylation of the epidermal growth factor receptor causes potentiation of signal transduction: role of receptor down-regulation, Steven J. Theroux, Krista Stanley, Debra A. Campbell, and Roger J. Davis

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Increased oncogenic potential of ErbB is associated with the loss of a COOH-terminal domain serine phosphorylation site, Steven J. Theroux, Cherie A. Taglienti, Nandini Nair, Janice L. Countaway, Harriet L. Robinson, and Roger J. Davis