Title
Regulation of the immune response by stress-activated protein kinases
UMMS Affiliation
Program in Molecular Medicine
Publication Date
3-1-2009
Document Type
Article
Disciplines
Biochemistry | Cell Biology | Cellular and Molecular Physiology | Immunity | Molecular Biology
Abstract
Activation of immune cells to mediate an immune response is often triggered by potential 'danger' or 'stress' stimuli that the organism receives. Within the mitogen-activated protein kinases (MAPKs) family, the stress-activated protein kinase (SAPK) group was defined as group of kinases that activated by stimuli that cause cell stress. In the immune cells, SAPKs are activated by antigen receptors (B- or T-cell receptors), Toll-like receptors, cytokine receptors, and physical-chemical changes in the environment among other stimuli. The SAPKs are established to be important mediators of intracellular signaling during adaptive and innate immune responses. Here we summarize what is currently known about the role of two sub-groups of SAPKs - c-Jun NH(2)-terminal kinase and p38 MAPK-in the function of specific components of the immune system and the overall contribution to the immune response.
DOI of Published Version
10.1111/j.1600-065X.2008.00744.x
Source
Immunol Rev. 2009 Mar;228(1):212-24. doi: 10.1111/j.1600-065X.2008.00744.x. Link to article on publisher's site
Journal/Book/Conference Title
Immunological reviews
Related Resources
PubMed ID
19290930
Repository Citation
Rincon, Mercedes and Davis, Roger J., "Regulation of the immune response by stress-activated protein kinases" (2009). Davis Lab Publications. 73.
https://escholarship.umassmed.edu/davis/73