Title

TNF and MAP kinase signalling pathways

UMMS Affiliation

Program in Molecular Medicine

Publication Date

6-1-2014

Document Type

Article

Subjects

Animals; Humans; *MAP Kinase Signaling System; Tumor Necrosis Factor-alpha

Disciplines

Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology

Abstract

The binding of tumour necrosis factor alpha (TNFalpha) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNFalpha) that contribute to the biological activity of TNFalpha. MAP kinases therefore function both upstream and down-stream of signalling by TNFalpha receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNFalpha.

Keywords

ERK, JNK, MAP kinase, TNF, p38 MAP kinase

DOI of Published Version

10.1016/j.smim.2014.02.009

Source

Semin Immunol. 2014 Jun;26(3):237-45. doi: 10.1016/j.smim.2014.02.009. Epub 2014 Mar 16. Link to article on publisher's site

Journal/Book/Conference Title

Seminars in immunology

Related Resources

Link to Article in PubMed

PubMed ID

24647229

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