Title

TNFalpha-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38alpha MAPK Pathway

UMMS Affiliation

Program in Molecular Medicine; UMass Metabolic Network

Publication Date

2-8-2016

Document Type

Article

Disciplines

Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology

Abstract

Smac mimetics (SMs), a class of drugs that can promote tumor cell death, represent a potential therapeutic strategy for the treatment of cancer. In this issue of Cancer Cell, Lalaoui et al. (2016) report that SM efficacy can be potently increased by inhibition of the p38alpha MAPK/MK2 signaling pathway.

DOI of Published Version

10.1016/j.ccell.2016.01.008

Source

Cancer Cell. 2016 Feb 8;29(2):131-3. doi: 10.1016/j.ccell.2016.01.008. Link to article on publisher's site

Journal/Book/Conference Title

Cancer cell

Related Resources

Link to Article in PubMed

PubMed ID

26859448