TNFalpha-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38alpha MAPK Pathway
Program in Molecular Medicine; UMass Metabolic Network
Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology
Smac mimetics (SMs), a class of drugs that can promote tumor cell death, represent a potential therapeutic strategy for the treatment of cancer. In this issue of Cancer Cell, Lalaoui et al. (2016) report that SM efficacy can be potently increased by inhibition of the p38alpha MAPK/MK2 signaling pathway.
DOI of Published Version
Cancer Cell. 2016 Feb 8;29(2):131-3. doi: 10.1016/j.ccell.2016.01.008. Link to article on publisher's site
Girnius N, Davis RJ. (2016). TNFalpha-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38alpha MAPK Pathway. Davis Lab Publications. https://doi.org/10.1016/j.ccell.2016.01.008. Retrieved from https://escholarship.umassmed.edu/davis/20