Research Data and Datasets


Department of Pediatrics; Department of Quantitative Health Sciences

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Endocrinology, Diabetes, and Metabolism | Pediatrics


Background: The health consequences of lactose intolerance (LI) are unclear.

Aims: To investigate the effects of LI on stature and vitamin D status.

Hypotheses: LI subjects will have similar heights and vitamin D status as controls.

Subjects and Methods: Prepubertal children of ages 3-12 years with LI (n=38, age 8.61 ± 3.08y, male/female 19/19) were compared to healthy, age- and gender-matched controls (n=49, age 7.95±2.64, male/female 28/21). Inclusion criteria: prepubertal status (boys: testicular volume

Results: There was no significant difference in 25(OH)D between the LI and non-LI subjects (60.1±21.1, vs. 65.4 ± 26.1 nmol/L, p = 0.29). Upon stratification into normal weight (BMI percentile) vs. overweight/obese (BMI ≥85th percentile), the normal weight controls had significantly higher 25(OH)D level than both the normal weight LI children (78.3 ± 32.6 vs. 62.9 ± 23.2, p = 0.025), and the overweight/obese LI children (78.3±32.6 vs. 55.3±16.5, p = 0.004). Secondly, there was no overall difference in height z-score between the LI children and controls. The normal weight LI patients had similar height as normal controls (-0.46 ± 0.89 vs. -0.71 ± 1.67, p = 0.53), while the overweight/obese LI group was taller than the normal weight controls (0.36 ± 1.41 vs. -0.71 ± 1.67, p = 0.049), and of similar height as the overweight/obese controls (0.36 ± 1.41 vs. 0.87 ± 1.45, p = 0.28). MPTH z-score was similar between the groups.

Conclusion: Short stature and vitamin D deficiency are not features of LI in prepubertal children.


Vitamin D deficiency, Lactose intolerance, Children, Obesity, Hydrogen, Body Mass Index, Short stature


This dataset (.csv file, 11 KB) is the primary data source for the following published study: Setty-Shah N, Maranda L, Candela N, Fong J, Dahod I, et al. (2013) Lactose Intolerance: Lack of Evidence for Short Stature or Vitamin D Deficiency in Prepubertal Children. PLoS ONE 8(10): e78653. doi:10.1371/journal.pone.0078653



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