Poster Presentations

Date

2014-05-20

Document Type

Poster Abstract

Description

Aging in men is associated with decreases in serum testosterone (T) and a decline in cognitive abilities. We sought to clarify the relationship between T, aging and cognition using the common marmoset (callithrix jacchus), which has been shown to be a useful model of human aging. Ten castrated male marmosets (ages 3-8) were given weekly injections of either T cypionate dissolved in cottonseed oil (T, n = 5) or cottonseed oil alone (controls, n = 5). Cognitive function was assessed with two tasks, the object reversals (OR) and the delayed response (DR). Marmoset behavior was recorded twice daily using a modified frequency scoring system, measuring 20 target behaviors in 15-s intervals over 5-min. For the OR task, no effect of group (F (1,8) = .51, p = .50), reversal (F (3,24) = .527, p = .67), or group x reversal interactions (F (3,24) = .640, p = .60) was found in the number of correct trials. There was a significant effect of outcome on response latency, with all monkeys having longer latencies on incorrect trials (F (1,2451) = 45.36, p

Comments

Abstract of poster presented at the 2014 UMass Center for Clinical and Translational Science Research Retreat, held on May 20, 2014 at the University of Massachusetts Medical School, Worcester, Mass.

DOI

10.13028/afrp-8j96

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May 20th, 12:30 PM

Testosterone Treatment Does Not Facilitate Prefrontal Cortex Mediated Cognition in Male Marmosets (callithrix jacchus)

Aging in men is associated with decreases in serum testosterone (T) and a decline in cognitive abilities. We sought to clarify the relationship between T, aging and cognition using the common marmoset (callithrix jacchus), which has been shown to be a useful model of human aging. Ten castrated male marmosets (ages 3-8) were given weekly injections of either T cypionate dissolved in cottonseed oil (T, n = 5) or cottonseed oil alone (controls, n = 5). Cognitive function was assessed with two tasks, the object reversals (OR) and the delayed response (DR). Marmoset behavior was recorded twice daily using a modified frequency scoring system, measuring 20 target behaviors in 15-s intervals over 5-min. For the OR task, no effect of group (F (1,8) = .51, p = .50), reversal (F (3,24) = .527, p = .67), or group x reversal interactions (F (3,24) = .640, p = .60) was found in the number of correct trials. There was a significant effect of outcome on response latency, with all monkeys having longer latencies on incorrect trials (F (1,2451) = 45.36, p