Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
UMass Chan Affiliations
Department of Cell BiologyDocument Type
Journal ArticlePublication Date
2006-03-28Keywords
AnimalsMicrofilaments
Models, Biological
Muscle Contraction
Muscle, Skeletal
Muscle, Smooth
Myosin Subfragments
Myosins
Cell Biology
Metadata
Show full item recordAbstract
Myosin filaments interact with actin to generate muscle contraction and many forms of cell motility. X-ray and electron microscopy (EM) studies have revealed the general organization of myosin molecules in relaxed filaments, but technical difficulties have prevented a detailed description. Recent studies using improved ultrastructural and image analysis techniques are overcoming these problems. Three-dimensional reconstructions using single-particle methods have provided many new insights into the organization of the myosin heads and tails. Docking of atomic structures into cryo-EM density maps suggests how regulated myosin filaments are 'switched off', bringing about muscle relaxation. Additionally, sequence analysis suggests probable interactions between myosin tails in the backbone, whereas crystallographic and EM studies are starting to reveal tail interactions directly in three dimensions.Source
Curr Opin Struct Biol. 2006 Apr;16(2):204-12. Epub 2006 Mar 24. Link to article on publisher's siteDOI
10.1016/j.sbi.2006.03.006Permanent Link to this Item
http://hdl.handle.net/20.500.14038/27660PubMed ID
16563742Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.sbi.2006.03.006