Craig Lab Publications

Title

Tropomyosin and the steric mechanism of muscle regulation

UMMS Affiliation

Department of Cell Biology

Publication Date

2-13-2009

Document Type

Article

Subjects

Actins; Adenosine Triphosphate; Animals; Calcium; Humans; Kinetics; Microfilaments; Models, Biological; Models, Molecular; Molecular Conformation; Muscles; Myosins; Protein Conformation; Protein Structure, Tertiary; Tropomyosin

Disciplines

Cell Biology

Abstract

Contraction in all muscles must be precisely regulated and requisite control systems must be able to adjust to changes in physiological and myopathic stimuli. In this chapter, we outline the structural evidence for a steric mechanism that governs muscle activity. The mechanism involves calcium and myosin induced changes in the position of tropomyosin along actin-based thin filaments. This process either blocks or uncovers myosin crossbridge binding sites on actin and consequently regulates crossbridge cycling on thin filaments, the sliding of thin and thick filaments and muscle shortening and force production.

Source

Adv Exp Med Biol. 2008;644:95-109.

Journal/Book/Conference Title

Advances in experimental medicine and biology

Related Resources

Link to Article in PubMed

PubMed ID

19209816

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