Title

Platelets and Immunity: Going Viral

UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine

Publication Date

2020-07-01

Document Type

Editorial

Disciplines

Cardiovascular Diseases | Fluids and Secretions | Hemic and Lymphatic Diseases | Immunity | Immunology of Infectious Disease | Infectious Disease | Microbiology | Virus Diseases

Abstract

Platelets are the major blood component bridging immunity and thrombosis. Abundant in the circulation, platelets encounter pathogens at a higher rate than any circulating leukocyte. Viral particles of various blood-borne pathogens such as HIV,1 dengue,2 or even respiratory viruses such as influenza3 are found inside human platelets. Viral infections with these viruses,4 as well as the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), can lead to thrombocytopenia5 along with thrombotic complications6–8 in patients. The presence of internalized viral particles, thrombocytopenia, and thrombosis implicates platelets as active participants in immunity during viral infections.

Keywords

COVID-19, Editorials, HIV, blood-borne pathogens, platelets, thrombosis

DOI of Published Version

10.1161/ATVBAHA.120.314620

Source

Koupenova M, Freedman JE. Platelets and Immunity: Going Viral. Arterioscler Thromb Vasc Biol. 2020 Jul;40(7):1605-1607. doi: 10.1161/ATVBAHA.120.314620. Epub 2020 Jun 24. PMID: 32579477; PMCID: PMC7319043. Link to article on publisher's site

Journal/Book/Conference Title

Arteriosclerosis, thrombosis, and vascular biology

Related Resources

Link to Article in PubMed

PubMed ID

32579477

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