UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine

Publication Date

2020-05-29

Document Type

Article Postprint

Disciplines

Cardiology | Cardiovascular Diseases | Fluids and Secretions | Immunology and Infectious Disease | Infectious Disease | Virus Diseases

Abstract

For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during COVID‐19.

Keywords

platelets, COVID-19, SARS-CoV-2, immunity, thrombosis

Rights and Permissions

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

DOI of Published Version

10.1002/rth2.12397

Source

Koupenova M. Potential Role of Platelets in COVID‐19: Implications for Thrombosis. Res Pract Thromb Haemost. 2020 May 29:10.1002/rth2.12397. doi: 10.1002/rth2.12397. PMCID: PMC7283793. Link to article on publisher website

Journal/Book/Conference Title

Research and Practice in Thrombosis and Haemostasis

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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