SARS-CoV-2 and COVID-19: A genetic, epidemiological, and evolutionary perspective

UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine

Publication Date


Document Type



Biochemistry, Biophysics, and Structural Biology | Ecology and Evolutionary Biology | Genetics and Genomics | Immunology and Infectious Disease | Infectious Disease | Virology | Virus Diseases


In less than five months, COVID-19 has spread from a small focus in Wuhan, China, to more than 5 million people in almost every country in the world, dominating the concern of most governments and public health systems. The social and political distresses caused by this epidemic will certainly impact our world for a long time to come. Here, we synthesize lessons from a range of scientific perspectives rooted in epidemiology, virology, genetics, ecology and evolutionary biology so as to provide perspective on how this pandemic started, how it is developing, and how best we can stop it.


Coevolution, Coronavirus, Host susceptibility, Immune system, Pandemics, Phylodynamics, COVID-19

DOI of Published Version



Sironi M, Hasnain SE, Phan T, Luciani F, Shaw MA, Sallum MA, Mirhashemi ME, Morand S, González-Candelas F; Editors of Infection, Genetics and Evolution. SARS-CoV-2 and COVID-19: A genetic, epidemiological, and evolutionary perspective. Infect Genet Evol. 2020 May 28:104384. doi: 10.1016/j.meegid.2020.104384. Epub ahead of print. PMID: 32473976; PMCID: PMC7256558. Link to article on publisher's site

Journal/Book/Conference Title

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

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Link to Article in PubMed

PubMed ID