Title

Should Clinicians Use Chloroquine or Hydroxychloroquine Alone or in Combination With Azithromycin for the Prophylaxis or Treatment of COVID-19

UMMS Affiliation

Department of Medicine

Publication Date

2020-05-13

Document Type

Article

Disciplines

Health Services Administration | Infectious Disease | Therapeutics | Virus Diseases

Abstract

Using chloroquine or hydroxychloroquine, with or without azithromycin, to prevent coronavirus disease (COVID-19) after infection with novel coronavirus (SARS-CoV-2) or to treat COVID-19 began to receive attention following preliminary reports from in vitro and human studies. While multiple studies are planned or under way, it is imperative to continually synthesize the results from the best available evidence to inform point-of-care decisions about the use of chloroquine or hydroxychloroquine. These practice points are based on a rapid and living systematic evidence review conducted by the University of Connecticut Health Outcomes, Policy, and Evidence Synthesis Group and will be updated as new evidence becomes available. The practice points development and update methods are included in the Appendix. This version of the practice points, based on an evidence review conducted on 17 April 2020, was approved by the American College of Physicians Board of Regents on 4 May 2020 and submitted to Annals of Internal Medicine on 6 May 2020.

Keywords

chloroquine, hydroxychloroquine, azithromycin, coronavirus disease, COVID-19

DOI of Published Version

10.7326/M20-1998

Source

Qaseem A, Yost J, Etxeandia-Ikobaltzeta I, Miller MC, Abraham GM, Obley AJ, Forciea MA, Jokela JA, Humphrey LL. Should Clinicians Use Chloroquine or Hydroxychloroquine Alone or in Combination With Azithromycin for the Prophylaxis or Treatment of COVID-19? Ann Intern Med. 2020 May 13. doi: 10.7326/M20-1998. Epub ahead of print. Erratum in: Ann Intern Med. 2020 May 26;: PMID: 32422063. Link to article on publisher's site

Journal/Book/Conference Title

Annals of internal medicine

Related Resources

Link to Article in PubMed

PubMed ID

32422063

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