UMMS Affiliation

School of Medicine; Department of Medicine, Division of Hematology Oncology

Publication Date


Document Type



Hematology | Hemic and Lymphatic Diseases | Immunoprophylaxis and Therapy | Infectious Disease | Virus Diseases


Immune thrombocytopenic purpura (ITP) is a rare hematologic condition through to affect 3.3 in 100,000 adults per year in the United States. Many cases of immune thrombocytopenia are diagnosed incidentally with laboratory tests that reveal low platelet count, without a clear cause. However, when platelet counts are very low, patients may show signs of bleeding. Here we present the case of a 24-year-old female with mucocutaneous bleeding ten days after receiving her first dose of SARS-CoV-2 vaccine, who was subsequently found to have severe thrombocytopenia. Extensive work up for new thrombocytopenia was unremarkable suggesting a diagnosis of ITP, potentially secondary to vaccination. Empiric treatment with glucocorticoids was initiated without response prompting the use of intravenous immunoglobulin G. The patient was discharged on hospital day five with a platelet count over 20,000 platelets per microliter. In summary, ITP is a potential sequela of the SARS-CoV-2 vaccine, and otherwise healthy young individuals may be at risk for hematologic side effects.


Coronavirus vaccine, immune reactions, thrombocytopenia

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI of Published Version



Cooper KM, Switzer B. Severe immune thrombocytopenic purpura after SARS-CoV-2 vaccine. Arch Clin Cases. 2021 Oct 27;8(2):31-36. doi: 10.22551/2021.31.0802.10182. PMID: 34754937; PMCID: PMC8565691. Link to article on publisher's site

Journal/Book/Conference Title

Archive of clinical cases

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Link to Article in PubMed

PubMed ID


Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License