A Splenic Infarction Related to Parainfluenza Infection in a Patient with AML: Lessons for COVID-19

UMMS Affiliation

Department of Medicine, Division of Hematology Oncology; School of Medicine

Publication Date


Document Type



Cardiovascular Diseases | Hemic and Lymphatic Diseases | Infectious Disease | Pathological Conditions, Signs and Symptoms | Virus Diseases


Infection related thrombosis is a well-known entity. Antigen burden, immune response, complement activation, pro-coagulant condition, and smoking are only a few amongst the multiple risk factors which interplay in the development of thrombosis in any given case. Viral infections are amongst the many inciting factors known to predispose a prothrombotic state. We hereby report a known case of acute myelogenous leukemia, status post allogeneic stem cell trans-plantation who presented with two discrete episodes of sore throat and left upper quadrant pain. Infectious workup confirmed parainfluenza virus 3 on the first occasion, and rhinovirus infection on the second occasion. Computed tomography of the abdomen during both times suggested a splenic infarction. A comprehensive thrombotic workup was negative which suggested the diagnosis of viral infection-related splenic infarction. This case highlights the importance of caring for the potential eventualities of coagulopathy in cancer and other immunocompromised patients infected during the COVID-19 pandemic.

DOI of Published Version



Sahu KK, E Vogt B, Shanahan L, Cerny J. A Splenic Infarction Related to Parainfluenza Infection in a Patient with AML: Lessons for COVID-19. Acta Biomed. 2021 Sep 2;92(4):e2021256. doi: 10.23750/abm.v92i4.11095. PMID: 34487090. Link to article on publisher's site

Journal/Book/Conference Title

Acta bio-medica : Atenei Parmensis

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Link to Article in PubMed

PubMed ID