Coronavirus disease 2019 and clinical research in U.S. nursing homes
Meyers Primary Care Institute; Department of Medicine, Division of Geriatric Medicine
Clinical Trials | Geriatrics | Immunology and Infectious Disease | Infectious Disease | Microbiology | Patient Safety | Virus Diseases
The ongoing coronavirus disease 2019 (COVID-19) pandemic has revealed the extreme vulnerability of residents of our nation's more than 15,000 nursing homes. Fewer than 1% of America's population reside in nursing homes, but as reported by the COVID-19 Tracking Project, “this tiny fraction of the country accounts for 35% of U.S. COVID-19 deaths.” Moreover, COVID-19 has disproportionately affected nursing homes with a higher proportion of Black and Hispanic residents.
Despite these sobering statistics, the U.S. clinical research enterprise has largely ignored the nursing home population in conducting clinical research on COVID-19. Of the 1.3 million residents of U.S. nursing homes, only a few hundred have participated in randomized controlled trials relating to COVID-19. And while nursing home residents were prioritized for vaccination in the initial COVID-19 allocation phase in the United States, this population was effectively excluded from the pivotal clinical trials of vaccines assessing efficacy and safety.
The dire need for scientific evidence to address the escalating crisis in nursing homes became apparent nearly immediately following the onset of the pandemic. Infection prevention and control strategies, therapeutics, vaccine safety and efficacy, and vaccine rollout efforts all would have benefited from rigorous research-based approaches. However, such efforts were impossible not only due to the chaos and lockdowns of nursing homes that occurred with the rapid spread of the virus, but because of circumstances in nursing homes that have existed for decades.
In this Commentary, we describe issues that have challenged the conduct of clinical research in nursing homes before and during the pandemic, and which will continue to challenge such efforts into the future.
coronavirus disease 2019, COVID-19, clinical research, nursing homes, nursing home population
DOI of Published Version
Quinn CC, Adams AS, Magaziner JS, Gurwitz JH. Coronavirus disease 2019 and clinical research in U.S. nursing homes. J Am Geriatr Soc. 2021 Apr 19. doi: 10.1111/jgs.17191. Epub ahead of print. PMID: 33872385. Link to article on publisher's site
Journal of the American Geriatrics Society
Quinn CC, Adams AS, Magaziner JS, Gurwitz JH. (2021). Coronavirus disease 2019 and clinical research in U.S. nursing homes. COVID-19 Publications by UMass Chan Authors. https://doi.org/10.1111/jgs.17191. Retrieved from https://escholarship.umassmed.edu/covid19/233