SARS-CoV-2 Vaccination and Solid Organ Transplant Patients: Data Needed to Inform Safety and Efficacy
Department of Medicine, Division of Infectious Diseases and Immunology
Immunology and Infectious Disease | Infectious Disease | Surgical Procedures, Operative | Virus Diseases
Solid organ transplant (SOT) recipients appear to have higher rates of mortality from COVID-19 when compared to other populations, attributed to underlying immunosuppression and concomitant co-morbidities.1 Such findings are consistent with other respiratory viral infections that are associated with an increased risk of morbidity and mortality in immunocompromised hosts.2 Further, these patients experience prolonged SARS-CoV-2 shedding which has been linked to emergence of viral mutants. Prolonged shedding also poses a risk of transmission and requires prolonged isolation, potentially leading to delays in medical care.
SARS-CoV-2, COVID-19, vaccination, transplantation
DOI of Published Version
Ison MG, Avery R, Blumberg E, Chin-Hong P, Halasa N, Kaul D, Pergam S, Theodoropoulos NM, Wolfe CR. SARS-CoV-2 Vaccination and Solid Organ Transplant Patients: Data Needed to Inform Safety and Efficacy. Transplantation. 2021 Mar 10. doi: 10.1097/TP.0000000000003747. Epub ahead of print. PMID: 33724250. Link to article on publisher's site
Ison MG, Avery R, Blumberg E, Chin-Hong P, Halasa N, Kaul D, Pergam S, Theodoropoulos NM, Wolfe CR. (2021). SARS-CoV-2 Vaccination and Solid Organ Transplant Patients: Data Needed to Inform Safety and Efficacy. COVID-19 Publications by UMass Chan Authors. https://doi.org/10.1097/TP.0000000000003747. Retrieved from https://escholarship.umassmed.edu/covid19/199