UMMS Affiliation
Department of Medicine
Publication Date
2021-02-08
Document Type
Article Postprint
Disciplines
Amino Acids, Peptides, and Proteins | Hemic and Immune Systems | Immunology of Infectious Disease | Immunoprophylaxis and Therapy | Infectious Disease | Virology | Virus Diseases
Abstract
The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small and large animal models. More significantly, the co-delivery of DNA and protein components at the same time elicited full protection against intratracheal challenge of SARS-CoV-2 viruses in immunized rhesus macaques. As both DNA and protein vaccines have been proven safe in previous human studies, and DNA vaccines are capable of eliciting germinal center B cell development, which is critical for high -affinity memory B cell responses, the DNA and protein co-delivery vaccine approach has great potential to serve as a safe and effective approach to develop COVID-19 vaccines that provide long-term protection.
Keywords
DNA vaccine, COVID-19, SARS-CoV-2, non-human primate, protein vaccine, spike glycoprotein
Rights and Permissions
This is an Accepted Manuscript version of the following article: Emerg Microbes Infect. 2021 Feb 8:1-19. doi: 10.1080/22221751.2021.1887767. Accepted manuscript posted as allowed by the publisher's green open access sharing policy at https://authorservices.taylorandfrancis.com/publishing-open-access/.
DOI of Published Version
10.1080/22221751.2021.1887767
Source
Li Y, Bi Y, Xiao H, Yao Y, Liu X, Hu Z, Duan J, Yang Y, Li Z, Li Y, Zhang H, Ding C, Yang J, Li H, He Z, Liu L, Hu G, Liu S, Che Y, Wang S, Li Q, Lu S, Cun W. A Novel DNA and Protein Combination COVID-19 Vaccine Formulation Provides Full Protection against SARS-CoV-2 in Rhesus Macaques. Emerg Microbes Infect. 2021 Feb 8:1-19. doi: 10.1080/22221751.2021.1887767. Epub ahead of print. PMID: 33555988. Link to article on publisher's site
Journal/Book/Conference Title
Emerging microbes and infections
Related Resources
PubMed ID
33555988
Repository Citation
Li Y, Hu G, Wang S, Li Q, Lu S, Cun W. (2021). A Novel DNA and Protein Combination COVID-19 Vaccine Formulation Provides Full Protection against SARS-CoV-2 in Rhesus Macaques. COVID-19 Publications by UMMS Authors. https://doi.org/10.1080/22221751.2021.1887767. Retrieved from https://escholarship.umassmed.edu/covid19/180
Included in
Amino Acids, Peptides, and Proteins Commons, Hemic and Immune Systems Commons, Immunology of Infectious Disease Commons, Immunoprophylaxis and Therapy Commons, Infectious Disease Commons, Virology Commons, Virus Diseases Commons
Comments
Full author list omitted for brevity. For the full list of authors, see article.